biostudies-literatureUnknown12Sussmann RACFundação de Amparo à Pesquisa do Estado de São PauloMalaria is one of the most widespread parasitic diseases, especially in Africa, Southeast Asia and South America. One of the greatest problems for control of the disease is the emergence of drug resistance, which leads to a need for the development of new antimalarial compounds. The biosynthesis of isoprenoids has been investigated as part of a strategy to identify new targets to obtain new antimalarial drugs. Several isoprenoid quinones, including menaquinone-4 (MK-4/vitamin K2), α- and γ-tocopherol and ubiquinone (UQ) homologs UQ-8 and UQ-9, were previously detected in <i>in vitro</i> cultures of <i>Plasmodium falciparum</i> in asexual stages. Herein, we described for the first time the presence of phylloquinone (PK/vitamin K1) in <i>P. falciparum</i> and discuss the possible origins of Frontiers in cellular and infection microbiology869085https://www.ebi.ac.uk/biostudies/studies/S-EPMC9069557biostudies-literaturePresence of Phylloquinone in the Intraerythrocytic Stages of <i>Plasmodium falciparum</i>.PMC9069557Katzin AMDomenech-Carbo ASussmann RACKato MJMenchaca Vega DSCebrian-Torrejon GGabriel HBRios AGYamaguchi LFBofill Verdaguer IKimura EACrispim MfalsePresence of Phylloquinone in the Intraerythrocytic Stages of <i>Plasmodium falciparum</i>.Malaria is one of the most widespread parasitic diseases, especially in Africa, Southeast Asia and South America. One of the greatest problems for control of the disease is the emergence of drug resistance, which leads to a need for the development of new antimalarial compounds. The biosynthesis of isoprenoids has been investigated as part of a strategy to identify new targets to obtain new antimalarial drugs. Several isoprenoid quinones, including menaquinone-4 (MK-4/vitamin K2), α- and γ-tocopherol and ubiquinone (UQ) homologs UQ-8 and UQ-9, were previously detected in <i>in vitro</i> cultures of <i>Plasmodium falciparum</i> in asexual stages. Herein, we described for the first time the presence of phylloquinone (PK/vitamin K1) in <i>P. falciparum</i> and discuss the possible origins of 2022-01-01T00:00:00Z20222026-05-31T21:58:20.702Z2025-04-04T19:30:39.202ZS-EPMC90695573553132610.3389/fcimb.2022.869085