{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stevens JS"],"funding":["NICHD NIH HHS","NIA NIH HHS","NIMH NIH HHS"],"pagination":["1037-1049"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9069566"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["178(11)"],"pubmed_abstract":["<h4>Objective</h4>Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations.<h4>Methods</h4>A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments.<h4>Results</h4>Ta"],"journal":["The American journal of psychiatry"],"pubmed_title":["Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma."],"pmcid":["PMC9069566"],"funding_grant_id":["K01 MH118467","T32 MH017119","K00 MH119603","R03 HD094577","U01 MH110925","R01 HD079076","F33 AG005654"],"pubmed_authors":["Clifford GD","Rauch SL","Roeckner A","Jovanovic T","Neylan TC","Linnstaedt SD","Joormann J","Storrow AB","Harte SE","Pascual JL","McGrath ME","Beaudoin FL","Pizzagalli DA","House SL","Lewandowski C","Bruce SE","Kurz MC","Zeng D","Pietrzak RH","Elliott JM","Lebois LAM","Chang AM","Datner EM","Ressler KJ","O'Neil BJ","Harnett NG","Kessler RC","McLean SA","Stevens JS","Germine LT","Ely TD","Koenen KC","An X","van Rooij SJH","Domeier RM","Murty VP","Haran JP","Barch DM","Hendry PL","Punches BE","Lyons MS","Vincent N","Pearson C","Peak DA","Luna B","Sheridan JF","Musey PI","Sheikh S","Rathlev NK","Sanchez LD","Jones CW"],"additional_accession":[]},"is_claimable":false,"name":"Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.","description":"<h4>Objective</h4>Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations.<h4>Methods</h4>A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments.<h4>Results</h4>Ta","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-06-04T04:40:11.337Z","creation":"2025-02-19T01:30:01.631Z"},"accession":"S-EPMC9069566","cross_references":{"pubmed":["34645277"],"doi":["10.1176/appi.ajp.2021.20101526"]}}