{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Orrego-Hernandez J"],"funding":["Facultad de Ciencias, Universidad de los Andes","Departamento Administrativo de Ciencia, Tecnología e Innovación"],"pagination":["27318-27323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9070601"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(47)"],"pubmed_abstract":["A green process to access pyrazolo-fused 4-azafluorenones (indeno[1,2-<i>b</i>]pyrazolo[4,3-<i>e</i>]pyridines, IPP) 4a-x<i>via</i> the three-component reaction between indan-1,3-dione (1), benzaldehydes 2 and 5-amino-1-arylpyrazoles 3 is described. These compounds were successfully used as precursors of the novel dicyanovinylidene derivatives 7a-d containing different acceptor (A) or donor (D) aryl groups at position 4 of its fused system. The structures of products obtained (4a-x and 7a-d) were determined based on NMR experiments, HRMS analysis, and X-ray diffraction studies for 7b. The photophysical and computational studies of 7a-d showed that these products are modulable ICT fluorophores, even some preliminary tests revealed that these compounds could be used as fluorescent chemodosim"],"journal":["RSC advances"],"pubmed_title":["Pyrazolo-fused 4-azafluorenones as key reagents for the synthesis of fluorescent dicyanovinylidene-substituted derivatives."],"pmcid":["PMC9070601"],"funding_grant_id":["Project Code 120465843502"],"pubmed_authors":["Orrego-Hernandez J","Lizarazo C","Portilla J","Cobo J"],"additional_accession":[]},"is_claimable":false,"name":"Pyrazolo-fused 4-azafluorenones as key reagents for the synthesis of fluorescent dicyanovinylidene-substituted derivatives.","description":"A green process to access pyrazolo-fused 4-azafluorenones (indeno[1,2-<i>b</i>]pyrazolo[4,3-<i>e</i>]pyridines, IPP) 4a-x<i>via</i> the three-component reaction between indan-1,3-dione (1), benzaldehydes 2 and 5-amino-1-arylpyrazoles 3 is described. These compounds were successfully used as precursors of the novel dicyanovinylidene derivatives 7a-d containing different acceptor (A) or donor (D) aryl groups at position 4 of its fused system. The structures of products obtained (4a-x and 7a-d) were determined based on NMR experiments, HRMS analysis, and X-ray diffraction studies for 7b. The photophysical and computational studies of 7a-d showed that these products are modulable ICT fluorophores, even some preliminary tests revealed that these compounds could be used as fluorescent chemodosim","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-04T09:10:17.774Z","creation":"2025-04-04T09:10:17.774Z"},"accession":"S-EPMC9070601","cross_references":{"pubmed":["35529179"],"doi":["10.1039/c9ra04682h"]}}