{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(5)"],"submitter":["Dickson ZW"],"pubmed_abstract":["Low Complexity Regions (LCRs) are present in a surprisingly large number of eukaryotic proteins. These highly repetitive and compositionally biased sequences are often structurally disordered, bind promiscuously, and evolve rapidly. Frequently studied in terms of evolutionary dynamics, little is known about how LCRs affect the expression of the proteins which contain them. It would be expected that rapidly evolving LCRs are unlikely to be tolerated in strongly conserved, highly abundant proteins, leading to lower overall abundance in proteins which contain LCRs. To test this hypothesis and examine the associations of protein abundance and transcript abundance with the presence of LCRs, we have integrated high-throughput data from across mammals. We have found that LCRs are indeed associate"],"journal":["Molecular biology and evolution"],"pagination":["msac087"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9070799"],"repository":["biostudies-literature"],"pubmed_title":["Low Complexity Regions in Mammalian Proteins are Associated with Low Protein Abundance and High Transcript Abundance."],"pmcid":["PMC9070799"],"pubmed_authors":["Dickson ZW","Golding GB"],"additional_accession":[]},"is_claimable":false,"name":"Low Complexity Regions in Mammalian Proteins are Associated with Low Protein Abundance and High Transcript Abundance.","description":"Low Complexity Regions (LCRs) are present in a surprisingly large number of eukaryotic proteins. These highly repetitive and compositionally biased sequences are often structurally disordered, bind promiscuously, and evolve rapidly. Frequently studied in terms of evolutionary dynamics, little is known about how LCRs affect the expression of the proteins which contain them. It would be expected that rapidly evolving LCRs are unlikely to be tolerated in strongly conserved, highly abundant proteins, leading to lower overall abundance in proteins which contain LCRs. To test this hypothesis and examine the associations of protein abundance and transcript abundance with the presence of LCRs, we have integrated high-throughput data from across mammals. We have found that LCRs are indeed associate","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-18T12:06:53.205Z","creation":"2025-04-06T22:57:32.962Z"},"accession":"S-EPMC9070799","cross_references":{"pubmed":["35482425"],"doi":["10.1093/molbev/msac087"]}}