{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Timani KA"],"pubmed_abstract":["To date, there are a small number of nuclear-restricted proteins that have been reported to play a role in NF-κB signaling. However, the exact molecular mechanisms are not fully understood. Tip110 is a nuclear protein that has been implicated in multiple biological processes. In a previous study, we have shown that Tip110 interacts with oncogenic ubiquitin specific peptidase 15 (USP15) and that ectopic expression of Tip110 leads to re-distribution of USP15 from the cytoplasm to the nucleus. USP15 is known to regulate NF-κB activity through several mechanisms including modulation of IκBα ubiquitination. These findings prompted us to investigate the role of Tip110 in the NF-κB signaling pathway. We showed that Tip110 regulates NF-κB activity. The expression of Tip110 potentiated TNF-α-induce"],"journal":["Frontiers in oncology"],"pagination":["843157"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9070983"],"repository":["biostudies-literature"],"pubmed_title":["Tip110/SART3-Mediated Regulation of NF-κB Activity by Targeting IκBα Stability Through USP15."],"pmcid":["PMC9070983"],"pubmed_authors":["Liu Y","Whitmill A","He JJ","Timani KA","Rezaei S"],"additional_accession":[]},"is_claimable":false,"name":"Tip110/SART3-Mediated Regulation of NF-κB Activity by Targeting IκBα Stability Through USP15.","description":"To date, there are a small number of nuclear-restricted proteins that have been reported to play a role in NF-κB signaling. However, the exact molecular mechanisms are not fully understood. Tip110 is a nuclear protein that has been implicated in multiple biological processes. In a previous study, we have shown that Tip110 interacts with oncogenic ubiquitin specific peptidase 15 (USP15) and that ectopic expression of Tip110 leads to re-distribution of USP15 from the cytoplasm to the nucleus. USP15 is known to regulate NF-κB activity through several mechanisms including modulation of IκBα ubiquitination. These findings prompted us to investigate the role of Tip110 in the NF-κB signaling pathway. We showed that Tip110 regulates NF-κB activity. The expression of Tip110 potentiated TNF-α-induce","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T23:16:57.717Z","creation":"2025-04-04T23:16:57.717Z"},"accession":"S-EPMC9070983","cross_references":{"pubmed":["35530338"],"doi":["10.3389/fonc.2022.843157"]}}