biostudies-literatureUnknown12Timani KATo date, there are a small number of nuclear-restricted proteins that have been reported to play a role in NF-κB signaling. However, the exact molecular mechanisms are not fully understood. Tip110 is a nuclear protein that has been implicated in multiple biological processes. In a previous study, we have shown that Tip110 interacts with oncogenic ubiquitin specific peptidase 15 (USP15) and that ectopic expression of Tip110 leads to re-distribution of USP15 from the cytoplasm to the nucleus. USP15 is known to regulate NF-κB activity through several mechanisms including modulation of IκBα ubiquitination. These findings prompted us to investigate the role of Tip110 in the NF-κB signaling pathway. We showed that Tip110 regulates NF-κB activity. The expression of Tip110 potentiated TNF-α-induceFrontiers in oncology843157https://www.ebi.ac.uk/biostudies/studies/S-EPMC9070983biostudies-literatureTip110/SART3-Mediated Regulation of NF-κB Activity by Targeting IκBα Stability Through USP15.PMC9070983Liu YWhitmill AHe JJTimani KARezaei SfalseTip110/SART3-Mediated Regulation of NF-κB Activity by Targeting IκBα Stability Through USP15.To date, there are a small number of nuclear-restricted proteins that have been reported to play a role in NF-κB signaling. However, the exact molecular mechanisms are not fully understood. Tip110 is a nuclear protein that has been implicated in multiple biological processes. In a previous study, we have shown that Tip110 interacts with oncogenic ubiquitin specific peptidase 15 (USP15) and that ectopic expression of Tip110 leads to re-distribution of USP15 from the cytoplasm to the nucleus. USP15 is known to regulate NF-κB activity through several mechanisms including modulation of IκBα ubiquitination. These findings prompted us to investigate the role of Tip110 in the NF-κB signaling pathway. We showed that Tip110 regulates NF-κB activity. The expression of Tip110 potentiated TNF-α-induce2022-01-01T00:00:00Z20222025-04-04T23:16:57.717Z2025-04-04T23:16:57.717ZS-EPMC90709833553033810.3389/fonc.2022.843157