{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rosado J"],"funding":["Bundesministerium für Bildung und Forschung","NIMH NIH HHS","NINDS NIH HHS","NIH"],"pagination":["e1010069"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9071165"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(4)"],"pubmed_abstract":["Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle, composed of smooth endoplasmic reticulum, which is responsible for calcium sequestration and release into the spine head and neck. The spine apparatus has recently been linked to synaptic plasticity in adult human cortical neurons. While the morphological heterogeneity of spines and their intracellular organization has been extensively demonstrated in animal models, the influence of spine apparatus organelles on critical signaling pathways, such as calcium-mediated dynamics, is less well known in human dendritic spines. In this study we used se"],"journal":["PLoS computational biology"],"pubmed_title":["Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an \"all-or-nothing\" communication switch between the spine head and dendrite."],"pmcid":["PMC9071165"],"funding_grant_id":["BMBF 01GQ1804A","R01MH118930","R01 NS109498","R01 MH118930","1R01NS109498"],"pubmed_authors":["Haas CA","Vlachos A","Queisser G","Rosado J","Bui VD","Beck J"],"additional_accession":[]},"is_claimable":false,"name":"Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an \"all-or-nothing\" communication switch between the spine head and dendrite.","description":"Dendritic spines are highly dynamic neuronal compartments that control the synaptic transmission between neurons. Spines form ultrastructural units, coupling synaptic contact sites to the dendritic shaft and often harbor a spine apparatus organelle, composed of smooth endoplasmic reticulum, which is responsible for calcium sequestration and release into the spine head and neck. The spine apparatus has recently been linked to synaptic plasticity in adult human cortical neurons. While the morphological heterogeneity of spines and their intracellular organization has been extensively demonstrated in animal models, the influence of spine apparatus organelles on critical signaling pathways, such as calcium-mediated dynamics, is less well known in human dendritic spines. In this study we used se","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T12:55:19.385Z","creation":"2025-04-19T12:55:19.385Z"},"accession":"S-EPMC9071165","cross_references":{"pubmed":["35468131"],"doi":["10.1371/journal.pcbi.1010069"]}}