biostudies-literatureLazow MAThe Gold Hope ProjectReflections Of GraceCure Brain CancerRyan’s HopeLaurie’s Love FoundationAHRQ HHSWhitley’s WishesKeris KaresLove Chloe FoundationStorm the Heavens FundThe Cure Starts Now AustraliaLily Larue FoundationThe Isabella and Marcus FoundationSnapgrant.comThe DIPG CollaborativePray Hope BelieveAidan’s AvengersWayland Villars FoundationMarlee’s MissionRUN DIPGAmerican Childhood Cancer OrganizationRobert Connor Dawes Foundationthe Kyler Strong FoundationBenny’s WorldAubreigh’s ArmyMusella FoundationAustin StrongBrooke Healey FoundationLauren’s Fight for CureJeffrey Thomas Hayden FoundationThe Cure Starts Now FoundationGabriella’s Smile Foundation821-833https://www.ebi.ac.uk/biostudies/studies/S-EPMC9071293biostudies-literatureUnknown24(5)<h4>Background</h4>Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential.<h4>Methods</h4>Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two neuro-radiologists. Imaging features suggestive of alternative diagnoses included nonpontine origin, <50% pontine involvement, focally exophytic morphology, sharply defined margins, and/or marked diffusion restriction throughout.<h4>Results</h4>Among 286 patients with pathology from biopsy and/oNeuro-oncologyAccuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry.PMC9071293K12 HS026390Cooney TMEl-Ayadi MKilburn LSandler ESPacker RFuller CWagner LMZiegler DSGururangan SBandopadhayay PCheng SMinturn JEZaghloul MBartels ULeary SEGottardo NMonje-Deisseroth MLane AEl-Sheikh AGreiner RJGoldman SJones BVHansford JRDholaria HLeach JLDorris KDeWire MCohen KJCoven SLBlack KBouffet ESamson YTinkle CLFisher PGHawkins CDrissi RSevlever GGarcia Lombardi MLazow MAFouladi MChaney BKoschmann CFonseca AHassall TMa JDiez BTsui KAsher AfalseAccuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry.<h4>Background</h4>Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential.<h4>Methods</h4>Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two neuro-radiologists. Imaging features suggestive of alternative diagnoses included nonpontine origin, <50% pontine involvement, focally exophytic morphology, sharply defined margins, and/or marked diffusion restriction throughout.<h4>Results</h4>Among 286 patients with pathology from biopsy and/o2022-01-01T00:00:00Z2022 May2025-04-04T07:13:31.097Z2025-04-04T07:13:31.097ZS-EPMC90712933466897510.1093/neuonc/noab245