{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van Gennip ACE"],"funding":["NCATS NIH HHS","NHLBI NIH HHS"],"pagination":["843-855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9071571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["191(5)"],"pubmed_abstract":["Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. The retina allows for visualization of a microvascular bed that shares similarities with the cerebral microvasculature. We investigated the associations between baseline retinal arteriolar and venular calibers (central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE), respectively) and incident depressive symptoms in the Multi-Ethnic Study of Atherosclerosis (MESA). We used longitudinal data on 4,366 participants (mean age = 63.2 years; 48.5% women, 28.4% Black) without baseline depressive symptoms. Depressive symptoms, defined as Center for Epidemiologic Studies Depression Scale score ≥16 and/or use of an"],"journal":["American journal of epidemiology"],"pubmed_title":["Retinal Microvascular Caliber and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis."],"pmcid":["PMC9071571"],"funding_grant_id":["UL1 TR000040","HHSN268201500003C","N01HC95160","UL1 TR001420","N01HC95161","UL1 TR001079","N01HC95162","N01HC95163","N01HC95164","N01HC95165","N01HC95166","N01HC95167","N01HC95168","N01HC95169","N01HC95159","75N92020D00007","K01 HL149987","75N92020D00001","75N92020D00002","75N92020D00005","75N92020D00006","75N92020D00003","HHSN268201500003I","75N92020D00004"],"pubmed_authors":["Allen NB","van Sloten TT","Carnethon MR","van Gennip ACE","Klein BEK","Chirinos DA","Cotch MF","Sedaghat S","Stehouwer CDA"],"additional_accession":[]},"is_claimable":false,"name":"Retinal Microvascular Caliber and Incident Depressive Symptoms: The Multi-Ethnic Study of Atherosclerosis.","description":"Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. The retina allows for visualization of a microvascular bed that shares similarities with the cerebral microvasculature. We investigated the associations between baseline retinal arteriolar and venular calibers (central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE), respectively) and incident depressive symptoms in the Multi-Ethnic Study of Atherosclerosis (MESA). We used longitudinal data on 4,366 participants (mean age = 63.2 years; 48.5% women, 28.4% Black) without baseline depressive symptoms. Depressive symptoms, defined as Center for Epidemiologic Studies Depression Scale score ≥16 and/or use of an","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T04:37:56.34Z","creation":"2025-04-06T11:12:27.284Z"},"accession":"S-EPMC9071571","cross_references":{"pubmed":["34652423"],"doi":["10.1093/aje/kwab255"]}}