{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gao YQ"],"funding":["Northwest A and F University","National Natural Science Foundation of China","Chinese Universities Scientific Fund"],"pagination":["29005-29009"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9071822"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(50)"],"pubmed_abstract":["A bio-inspired synthesis of hybrid flavonoids from 2-hydroxylchalcone is described. Under the irradiation of 24 W CFL, 2-hydroxychalcone reacts with various nucleophiles to deliver structurally diverse hybrid flavonoids in good to excellent yields in the presence of a catalytic Brønsted acid. Moreover, moderate enantioselectivities could be obtained using a catalytic chiral phosphoric acid <i>via</i> counter anion directed addition. Based on mechanistic studies, the reaction is proposed to proceed <i>via</i> tandem double-bond isomerization/dehydrated cyclization of 2-hydroxychalcone to form a transient flavylium cation, which is <i>in situ</i> captured by nucleophiles to afford hybrid flavonoids."],"journal":["RSC advances"],"pubmed_title":["A bio-inspired synthesis of hybrid flavonoids from 2-hydroxychalcone driven by visible light."],"pmcid":["PMC9071822"],"funding_grant_id":["21672171","21722206"],"pubmed_authors":["Gao YQ","Xie W","He Y","Zhu L","Chen G","Xu D","Hou Y","Zhang SY"],"additional_accession":[]},"is_claimable":false,"name":"A bio-inspired synthesis of hybrid flavonoids from 2-hydroxychalcone driven by visible light.","description":"A bio-inspired synthesis of hybrid flavonoids from 2-hydroxylchalcone is described. Under the irradiation of 24 W CFL, 2-hydroxychalcone reacts with various nucleophiles to deliver structurally diverse hybrid flavonoids in good to excellent yields in the presence of a catalytic Brønsted acid. Moreover, moderate enantioselectivities could be obtained using a catalytic chiral phosphoric acid <i>via</i> counter anion directed addition. Based on mechanistic studies, the reaction is proposed to proceed <i>via</i> tandem double-bond isomerization/dehydrated cyclization of 2-hydroxychalcone to form a transient flavylium cation, which is <i>in situ</i> captured by nucleophiles to afford hybrid flavonoids.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-19T09:20:36.313Z","creation":"2025-04-19T09:20:36.313Z"},"accession":"S-EPMC9071822","cross_references":{"pubmed":["35528404"],"doi":["10.1039/c9ra07198a"]}}