{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye ZH"],"funding":["National Natural Science Foundation of China"],"pagination":["8513747"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9071859"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["<h4>Background</h4>Neoadjuvant immunotherapy is promising for locally advanced non-small-cell lung cancer (NSCLC). The <i>in situ</i> immune patterns, as a predictor of PD-1/PD-L1 blockade outcomes, of the primary tumor (PT) and metastatic lymph nodes (mLNs) are unknown.<h4>Methods</h4>Multiplex immunofluorescence staining and multispectral imaging were used to evaluate the <i>in situ</i> immune patterns of T cells (CD3+) and cytotoxic T cells (CD8+) in terms of density, location (center of tumor (CT) and invasive margin (IM)), and the PD-L1 expression status of tumor cells and stromal T cells of paired PTs and mLNs in 38 stage III NSCLCs.<h4>Results</h4>The densities of T cells and cytotoxic T cells were correlated between PTs and mLNs at both CT and IM. Higher densities of stromal T cell"],"journal":["Journal of immunology research"],"pubmed_title":["Different <i>In Situ</i> Immune Patterns between Primary Tumor and Lymph Node in Non-Small-Cell Lung Cancer: Potential Impact on Neoadjuvant Immunotherapy."],"pmcid":["PMC9071859"],"funding_grant_id":["82002407"],"pubmed_authors":["Long H","Ye ZH","Zhao ZR"],"additional_accession":[]},"is_claimable":false,"name":"Different <i>In Situ</i> Immune Patterns between Primary Tumor and Lymph Node in Non-Small-Cell Lung Cancer: Potential Impact on Neoadjuvant Immunotherapy.","description":"<h4>Background</h4>Neoadjuvant immunotherapy is promising for locally advanced non-small-cell lung cancer (NSCLC). The <i>in situ</i> immune patterns, as a predictor of PD-1/PD-L1 blockade outcomes, of the primary tumor (PT) and metastatic lymph nodes (mLNs) are unknown.<h4>Methods</h4>Multiplex immunofluorescence staining and multispectral imaging were used to evaluate the <i>in situ</i> immune patterns of T cells (CD3+) and cytotoxic T cells (CD8+) in terms of density, location (center of tumor (CT) and invasive margin (IM)), and the PD-L1 expression status of tumor cells and stromal T cells of paired PTs and mLNs in 38 stage III NSCLCs.<h4>Results</h4>The densities of T cells and cytotoxic T cells were correlated between PTs and mLNs at both CT and IM. Higher densities of stromal T cell","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-31T23:12:08.456Z","creation":"2024-11-12T02:28:07.812Z"},"accession":"S-EPMC9071859","cross_references":{"pubmed":["35528615"],"doi":["10.1155/2022/8513747"]}}