biostudies-literatureYi BNatural Science Foundation of Hunan ProvinceNational Natural Science Foundation of China29721-29725https://www.ebi.ac.uk/biostudies/studies/S-EPMC9071963biostudies-literatureUnknown9(51)A novel method for the synthesis of α-aminonitrile through visible-light-induced oxidative cyanation of <i>N</i>-aryltetrahydroisoquinoline with potassium thiocyanate has been developed. The process does not require the use of a photocatalyst, transition metal reagent, strong oxidizing agent, or toxic cyano-containing compound, which makes the reaction simple and green.RSC advancesOxidative cyanation of <i>N</i>-aryltetrahydroisoquinoline induced by visible light for the synthesis of α-aminonitrile using potassium thiocyanate as a "CN" agent.PMC90719632019JJ5010421772035Wen XLan DYi NXie YAu CTYan NYi BfalseOxidative cyanation of <i>N</i>-aryltetrahydroisoquinoline induced by visible light for the synthesis of α-aminonitrile using potassium thiocyanate as a "CN" agent.A novel method for the synthesis of α-aminonitrile through visible-light-induced oxidative cyanation of <i>N</i>-aryltetrahydroisoquinoline with potassium thiocyanate has been developed. The process does not require the use of a photocatalyst, transition metal reagent, strong oxidizing agent, or toxic cyano-containing compound, which makes the reaction simple and green.2019-01-01T00:00:00Z2019 Sep2025-04-19T09:19:37.413Z2025-04-19T09:19:37.413ZS-EPMC90719633553150110.1039/c9ra06120g