{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Nagarajan K"],"pubmed_abstract":["Antibiotic resistance represents one of the biggest challenges, and there is an urgent need for plant-based antimicrobial agents that enable managing this crisis effectively. In this work, we aimed to investigate the antibacterial activity of <i>Astragalus candolleanus</i> (<i>A. candolleanus</i>) hydromethanolic root extract against Gram-positive (<i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>) and Gram-negative (<i>Escherichia coli</i>, <i>Salmonella typhimurium</i>, <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, and <i>Kocuria rhizophila</i>) strains by the cup-plate method. The root was powdered and extracted with 70% methanol by cold maceration for 5 days. Preliminary phytochemical screening was performed with different solvents in the order of increasing pola"],"journal":["International journal of microbiology"],"pagination":["4584799"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072053"],"repository":["biostudies-literature"],"pubmed_title":["Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of <i>Astragalus candolleanus</i> against Clinically Significant Bacterial Strains."],"pmcid":["PMC9072053"],"pubmed_authors":["Goel R","Ghai R","Genovese C","Prasad T","Kalaivani M","Teotia AK","Nagarajan K","D'Angeli F","Grover P","Varshney G"],"additional_accession":[]},"is_claimable":false,"name":"Identification of Potent Bioassay Guided Terpenoid and Glycoside Root Fractions of <i>Astragalus candolleanus</i> against Clinically Significant Bacterial Strains.","description":"Antibiotic resistance represents one of the biggest challenges, and there is an urgent need for plant-based antimicrobial agents that enable managing this crisis effectively. In this work, we aimed to investigate the antibacterial activity of <i>Astragalus candolleanus</i> (<i>A. candolleanus</i>) hydromethanolic root extract against Gram-positive (<i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>) and Gram-negative (<i>Escherichia coli</i>, <i>Salmonella typhimurium</i>, <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, and <i>Kocuria rhizophila</i>) strains by the cup-plate method. The root was powdered and extracted with 70% methanol by cold maceration for 5 days. Preliminary phytochemical screening was performed with different solvents in the order of increasing pola","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T07:57:04.542Z","creation":"2024-11-09T03:42:01.709Z"},"accession":"S-EPMC9072053","cross_references":{"pubmed":["35528313"],"doi":["10.1155/2022/4584799"]}}