{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Valentino M"],"funding":["NICHD NIH HHS","NIGMS NIH HHS"],"pagination":["1465-1482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121(8)"],"pubmed_abstract":["The packaging of specific mRNAs into ribonucleoprotein granules called germ granules is required for germline proliferation and maintenance. During Drosophila germ granule development, mRNAs such as nanos (nos) and polar granule component (pgc) localize to germ granules through a stochastic seeding and self-recruitment process that generates homotypic clusters: aggregates containing multiple copies of a specific transcript. Germ granules vary in mRNA composition with respect to the different transcripts that they contain and their quantity. However, what influences germ granule mRNA composition during development is unclear. To gain insight into how germ granule mRNA heterogeneity arises, we created a computational model that simulates granule development. Although the model includes known"],"journal":["Biophysical journal"],"pubmed_title":["Computational modeling offers new insight into Drosophila germ granule development."],"pmcid":["PMC9072583"],"funding_grant_id":["R15 HD102960","R35 GM126967","F32 GM119200"],"pubmed_authors":["Valentino M","Ortega BM","Ulrich B","Farnum ED","Niepielko MG","Joiner DA","Doyle DA","Gavis ER"],"additional_accession":[]},"is_claimable":false,"name":"Computational modeling offers new insight into Drosophila germ granule development.","description":"The packaging of specific mRNAs into ribonucleoprotein granules called germ granules is required for germline proliferation and maintenance. During Drosophila germ granule development, mRNAs such as nanos (nos) and polar granule component (pgc) localize to germ granules through a stochastic seeding and self-recruitment process that generates homotypic clusters: aggregates containing multiple copies of a specific transcript. Germ granules vary in mRNA composition with respect to the different transcripts that they contain and their quantity. However, what influences germ granule mRNA composition during development is unclear. To gain insight into how germ granule mRNA heterogeneity arises, we created a computational model that simulates granule development. Although the model includes known","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-04T14:03:13.325Z","creation":"2025-04-06T23:07:58.353Z"},"accession":"S-EPMC9072583","cross_references":{"pubmed":["35288123"],"doi":["10.1016/j.bpj.2022.03.014"]}}