{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang H"],"funding":["Science and Technology Commission of Shanghai Municipality","Fudan University"],"pagination":["31474-31482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072619"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(54)"],"pubmed_abstract":["Combinatorial synthesis of (<i>E</i>)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562."],"journal":["RSC advances"],"pubmed_title":["Combinatorial synthesis and biological evaluations of (<i>E</i>)-β-trifluoromethyl vinylsulfones as antitumor agents."],"pmcid":["PMC9072619"],"funding_grant_id":["19ZR1407100","IDH1615098"],"pubmed_authors":["Li X","Lu Y","Zeng J","Zhou W","Kuang Y","Tang H"],"additional_accession":[]},"is_claimable":false,"name":"Combinatorial synthesis and biological evaluations of (<i>E</i>)-β-trifluoromethyl vinylsulfones as antitumor agents.","description":"Combinatorial synthesis of (<i>E</i>)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-05T13:23:46.59Z","creation":"2025-04-05T13:23:46.59Z"},"accession":"S-EPMC9072619","cross_references":{"pubmed":["35527921"],"doi":["10.1039/c9ra06368d"]}}