biostudies-literatureTang HScience and Technology Commission of Shanghai MunicipalityFudan University31474-31482https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072619biostudies-literatureUnknown9(54)Combinatorial synthesis of (<i>E</i>)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562.RSC advancesCombinatorial synthesis and biological evaluations of (<i>E</i>)-β-trifluoromethyl vinylsulfones as antitumor agents.PMC907261919ZR1407100IDH1615098Li XLu YZeng JZhou WKuang YTang HfalseCombinatorial synthesis and biological evaluations of (<i>E</i>)-β-trifluoromethyl vinylsulfones as antitumor agents.Combinatorial synthesis of (<i>E</i>)-β-trifluoromethyl vinylsulfones is accomplished through a reaction of alkynes, Togni reagent, and sodium benzenesulfinates in DMSO under metal-free conditions at room temperature. These compounds are evaluated in several assays against different tumor cells. Some hits are identified against ES-2, HO-8910, and K562.2019-01-01T00:00:00Z2019 Oct2025-04-05T13:23:46.59Z2025-04-05T13:23:46.59ZS-EPMC90726193552792110.1039/c9ra06368d