{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Yan J"],"pubmed_abstract":["<h4>Aim</h4>To investigate the treating effect of Yiqi-Bushen-Tiaozhi (YBT) recipe on nonalcoholic steatohepatitis (NASH) mice, determine whether the outcome was associated with gut microbiota, and clarify the regulating mechanism.<h4>Methods</h4>NASH mice were induced by high-fat and high-fructose diets (HFFD). In the fifth week, mice in the YBT group were orally administrated YBT (22.12g·kg<sup>-1</sup>·d<sup>-1</sup>) daily for 12 weeks. Fresh stool of mice was collected at the 16<sup>th</sup> week for fecal 16S rDNA analysis. Hepatic pathology and biochemical indicators were used to reflect the improvement of YBT on hepatic inflammation and lipid metabolism in NASH mice. Quantitative real-time PCR (qRT-PCR) was used to verify the results of PICRUSt analysis.<h4>Results</h4>Results of t"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["824597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072834"],"repository":["biostudies-literature"],"pubmed_title":["Yiqi-Bushen-Tiaozhi Recipe Attenuated High-Fat and High-Fructose Diet Induced Nonalcoholic Steatohepatitis in Mice <i>via</i> Gut Microbiota."],"pmcid":["PMC9072834"],"pubmed_authors":["Liu Y","Yan J","Li J","Wu L","Chen Z","He B","Nie Y"],"additional_accession":[]},"is_claimable":false,"name":"Yiqi-Bushen-Tiaozhi Recipe Attenuated High-Fat and High-Fructose Diet Induced Nonalcoholic Steatohepatitis in Mice <i>via</i> Gut Microbiota.","description":"<h4>Aim</h4>To investigate the treating effect of Yiqi-Bushen-Tiaozhi (YBT) recipe on nonalcoholic steatohepatitis (NASH) mice, determine whether the outcome was associated with gut microbiota, and clarify the regulating mechanism.<h4>Methods</h4>NASH mice were induced by high-fat and high-fructose diets (HFFD). In the fifth week, mice in the YBT group were orally administrated YBT (22.12g·kg<sup>-1</sup>·d<sup>-1</sup>) daily for 12 weeks. Fresh stool of mice was collected at the 16<sup>th</sup> week for fecal 16S rDNA analysis. Hepatic pathology and biochemical indicators were used to reflect the improvement of YBT on hepatic inflammation and lipid metabolism in NASH mice. Quantitative real-time PCR (qRT-PCR) was used to verify the results of PICRUSt analysis.<h4>Results</h4>Results of t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-03-15T19:25:09.14Z","creation":"2025-04-06T19:46:22.308Z"},"accession":"S-EPMC9072834","cross_references":{"pubmed":["35531334"],"doi":["10.3389/fcimb.2022.824597"]}}