{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(4)"],"submitter":["Al-Zharani M"],"pubmed_abstract":["The pyrrolidine-2,4-dione derivatives were used to conduct a larvicidal test on <i>Culex quinquefasciatus</i> larvae of the second instar. Mannich base condensation method was used to synthesis the pyrrolidine-2,4-dione derivatives by grindstone method. The reaction conditions were mild, resulting in high yields. An analysis of the synthesized compounds was carried out using FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass spectrometry, and elemental analysis. Synthesized compounds (<b>1a-h</b>) were evaluated for larvicidal activities. Compound <b>1e</b> (LD<sub>50</sub>: 26.06 µg/mL), and <b>1f</b> (LD<sub>50</sub>: 26.89 µg/mL), and were notably more active against <i>Culex quinquefasciatus</i> than permethrin (LD<sub>50</sub>: 26.14 µg/mL). The docking studies also demonstrated that <"],"journal":["Saudi journal of biological sciences"],"pagination":["2389-2395"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072886"],"repository":["biostudies-literature"],"pubmed_title":["Mosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against <i>Culex quinquefasciatus</i> and molecular docking studies."],"pmcid":["PMC9072886"],"pubmed_authors":["Idhayadhulla A","Rudayni HA","Ali D","SurendraKumar R","Alarifi S","Al-Eissa MS","Al-Zharani M"],"additional_accession":[]},"is_claimable":false,"name":"Mosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against <i>Culex quinquefasciatus</i> and molecular docking studies.","description":"The pyrrolidine-2,4-dione derivatives were used to conduct a larvicidal test on <i>Culex quinquefasciatus</i> larvae of the second instar. Mannich base condensation method was used to synthesis the pyrrolidine-2,4-dione derivatives by grindstone method. The reaction conditions were mild, resulting in high yields. An analysis of the synthesized compounds was carried out using FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass spectrometry, and elemental analysis. Synthesized compounds (<b>1a-h</b>) were evaluated for larvicidal activities. Compound <b>1e</b> (LD<sub>50</sub>: 26.06 µg/mL), and <b>1f</b> (LD<sub>50</sub>: 26.89 µg/mL), and were notably more active against <i>Culex quinquefasciatus</i> than permethrin (LD<sub>50</sub>: 26.14 µg/mL). The docking studies also demonstrated that <","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-18T12:12:12.509Z","creation":"2025-04-06T21:50:58.001Z"},"accession":"S-EPMC9072886","cross_references":{"pubmed":["35531199"],"doi":["10.1016/j.sjbs.2021.12.003"]}}