biostudies-literatureUnknown29(4)Al-Zharani MThe pyrrolidine-2,4-dione derivatives were used to conduct a larvicidal test on <i>Culex quinquefasciatus</i> larvae of the second instar. Mannich base condensation method was used to synthesis the pyrrolidine-2,4-dione derivatives by grindstone method. The reaction conditions were mild, resulting in high yields. An analysis of the synthesized compounds was carried out using FTIR, ¹H NMR, ¹³C NMR, mass spectrometry, and elemental analysis. Synthesized compounds (<b>1a-h</b>) were evaluated for larvicidal activities. Compound <b>1e</b> (LD₅₀: 26.06 µg/mL), and <b>1f</b> (LD₅₀: 26.89 µg/mL), and were notably more active against <i>Culex quinquefasciatus</i> than permethrin (LD₅₀: 26.14 µg/mL). The docking studies also demonstrated that <Saudi journal of biological sciences2389-2395https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072886biostudies-literatureMosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against <i>Culex quinquefasciatus</i> and molecular docking studies.PMC9072886Idhayadhulla ARudayni HAAli DSurendraKumar RAlarifi SAl-Eissa MSAl-Zharani MfalseMosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against <i>Culex quinquefasciatus</i> and molecular docking studies.The pyrrolidine-2,4-dione derivatives were used to conduct a larvicidal test on <i>Culex quinquefasciatus</i> larvae of the second instar. Mannich base condensation method was used to synthesis the pyrrolidine-2,4-dione derivatives by grindstone method. The reaction conditions were mild, resulting in high yields. An analysis of the synthesized compounds was carried out using FTIR, ¹H NMR, ¹³C NMR, mass spectrometry, and elemental analysis. Synthesized compounds (<b>1a-h</b>) were evaluated for larvicidal activities. Compound <b>1e</b> (LD₅₀: 26.06 µg/mL), and <b>1f</b> (LD₅₀: 26.89 µg/mL), and were notably more active against <i>Culex quinquefasciatus</i> than permethrin (LD₅₀: 26.14 µg/mL). The docking studies also demonstrated that <2022-01-01T00:00:00Z2022 Apr2025-04-18T12:12:12.509Z2025-04-06T21:50:58.001ZS-EPMC90728863553119910.1016/j.sjbs.2021.12.003