biostudies-literatureUnknown9(55)Chaix AEuropean Regional Development FundPorous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming at pDNA complexation. The amino acid-based pDNA nanocarriers, displaying an average diameter of 295 nm, succeeded in transfection of HEK293 cells with an efficiency 300 times superior to "bare" porous silicon nanoparticles.RSC advances31895-31899https://www.ebi.ac.uk/biostudies/studies/S-EPMC9072902biostudies-literatureAmino-acid functionalized porous silicon nanoparticles for the delivery of pDNA.PMC9072902Durand JOCunin FKnezevic NPichon CMidoux PCueto-Diaz EDelalande AChaix AfalseAmino-acid functionalized porous silicon nanoparticles for the delivery of pDNA.Porous silicon nanoparticles as a novel platform in gene therapy, have shown to be an efficient vehicle for the delivery of nucleic acids in cells. For the first time, a family of porous silicon nanoparticles has been produced featuring an amino-acid functionalized cationic external surface aiming at pDNA complexation. The amino acid-based pDNA nanocarriers, displaying an average diameter of 295 nm, succeeded in transfection of HEK293 cells with an efficiency 300 times superior to "bare" porous silicon nanoparticles.2019-01-01T00:00:00Z2019 Oct2025-04-04T09:09:54.058Z2025-04-04T09:09:54.058ZS-EPMC90729023553079510.1039/c9ra05461h