{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen JS"],"funding":["Ministry of Science and Technology, Taiwan","National Chung-Hsing University"],"pagination":["33853-33862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9073715"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(58)"],"pubmed_abstract":["This work demonstrates the utilization of phosphotungstic acid (PTA) as a novel acidic catalyst for carbohydrate reactions, such as per-<i>O</i>-acetylation, regioselective <i>O</i>-4,6 benzylidene acetal formation, regioselective <i>O</i>-4 ring-opening, and glycosylation. These reactions are basic and salient during the synthesis of carbohydrate-based bioactive oligomers. Phosphotungstic acid's high acidity and eco-friendly character make it a tempting alternative to corrosive homogeneous acids. The various homogenous acid catalysts were replaced by the phosphotungstic acid solely for different carbohydrate reactions. It can be widely used as a catalyst for organic reactions as it is thermally stable and easy to handle. In our work, the reactions are operated smoothly under ambient condi"],"journal":["RSC advances"],"pubmed_title":["Phosphotungstic acid as a novel acidic catalyst for carbohydrate protection and glycosylation."],"pmcid":["PMC9073715"],"funding_grant_id":["MOST 107-2113-M-005-021"],"pubmed_authors":["Chen JS","Wu HR","Luo SY","Sankar A","Lin YJ","Huang PH","Liao CH","Wu SS"],"additional_accession":[]},"is_claimable":false,"name":"Phosphotungstic acid as a novel acidic catalyst for carbohydrate protection and glycosylation.","description":"This work demonstrates the utilization of phosphotungstic acid (PTA) as a novel acidic catalyst for carbohydrate reactions, such as per-<i>O</i>-acetylation, regioselective <i>O</i>-4,6 benzylidene acetal formation, regioselective <i>O</i>-4 ring-opening, and glycosylation. These reactions are basic and salient during the synthesis of carbohydrate-based bioactive oligomers. Phosphotungstic acid's high acidity and eco-friendly character make it a tempting alternative to corrosive homogeneous acids. The various homogenous acid catalysts were replaced by the phosphotungstic acid solely for different carbohydrate reactions. It can be widely used as a catalyst for organic reactions as it is thermally stable and easy to handle. In our work, the reactions are operated smoothly under ambient condi","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-26T15:16:53.086Z","creation":"2025-04-06T14:53:08.024Z"},"accession":"S-EPMC9073715","cross_references":{"pubmed":["35528919"],"doi":["10.1039/c9ra06170c"]}}