biostudies-literatureUnknown10(7)Ma X<h4>Background</h4>Community-acquired pneumonia (CAP) is often accompanied by changes in lipid metabolism. This study aimed to examine the changes in serum phospholipids (PLs) that may be useful for early disease stratification and as potential therapeutic targets in patients with CAP.<h4>Methods</h4>Serum samples from 58 patients hospitalized with CAP and 11 control samples were collected during admission between January 2017 and October 2018. Targeted lipidomic analysis was used to determine the concentrations of phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), and lysophosphatidylethanolamine (LPE). The Gene Expression Omnibus (GEO) database was used to evaluate the gene expression levels of key enzymes in the Lands cycle, and quantitative real-timAnnals of translational medicine395https://www.ebi.ac.uk/biostudies/studies/S-EPMC9073783biostudies-literatureTargeted lipidomics reveals phospholipids and lysophospholipids as biomarkers for evaluating community-acquired pneumonia.PMC9073783Zheng YZhao LHe YXie YChen LMa XYu WGao ZLi RYu YXu YfalseTargeted lipidomics reveals phospholipids and lysophospholipids as biomarkers for evaluating community-acquired pneumonia.<h4>Background</h4>Community-acquired pneumonia (CAP) is often accompanied by changes in lipid metabolism. This study aimed to examine the changes in serum phospholipids (PLs) that may be useful for early disease stratification and as potential therapeutic targets in patients with CAP.<h4>Methods</h4>Serum samples from 58 patients hospitalized with CAP and 11 control samples were collected during admission between January 2017 and October 2018. Targeted lipidomic analysis was used to determine the concentrations of phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), and lysophosphatidylethanolamine (LPE). The Gene Expression Omnibus (GEO) database was used to evaluate the gene expression levels of key enzymes in the Lands cycle, and quantitative real-tim2022-01-01T00:00:00Z2022 Apr2026-05-31T12:59:39.162Z2025-04-06T21:48:27.902ZS-EPMC90737833553095010.21037/atm-21-4008