biostudies-literatureUnknown20(5)EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on bovine milk osteopontin (bmOPN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF concerns OPN derived from bovine whey. The NF is intended to be used at a maximum use level of 151 mg/L, in infant formula (IF), follow-on formula (FoF) and ready-to-eat dairy-based meals for children up to 35 months of age. As compared to the concentrations naturally present in cow's milk and concentrations found in IF on the market reported in the literature, the proposed use level of the NF represents an about 10-fold higher concentration of bmOPN. The intended use levels of the NF would provide bmOPN at a concentration within the range of hEFSA journal. European Food Safety Authoritye07137https://www.ebi.ac.uk/biostudies/studies/S-EPMC9074041biostudies-literatureSafety of bovine milk osteopontin as a Novel food pursuant to Regulation (EU) 2015/2283.PMC9074041Vinceti MNaska ACastenmiller JEFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Marchelli RTsabouri SFrenzel TKnutsen HKNeuhauser-Berthold MThies FSchlatter JRTurck DSiani APoulsen MKearney JPelaez CMcArdle HJMangelsdorf IHeinonen MMaciuk AGelbmann WDe Henauw SPentieva KHirsch-Ernst KICubadda Fvan Loveren HMaradona MPfalseSafety of bovine milk osteopontin as a Novel food pursuant to Regulation (EU) 2015/2283.Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on bovine milk osteopontin (bmOPN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF concerns OPN derived from bovine whey. The NF is intended to be used at a maximum use level of 151 mg/L, in infant formula (IF), follow-on formula (FoF) and ready-to-eat dairy-based meals for children up to 35 months of age. As compared to the concentrations naturally present in cow's milk and concentrations found in IF on the market reported in the literature, the proposed use level of the NF represents an about 10-fold higher concentration of bmOPN. The intended use levels of the NF would provide bmOPN at a concentration within the range of h2022-01-01T00:00:00Z2022 May2025-04-05T09:57:44.625Z2025-04-05T09:57:44.625ZS-EPMC90740413557220210.2903/j.efsa.2022.7137