{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li CY"],"funding":["Ministry of Science and Technology, Taiwan","China Medical University, Taiwan","Kaohsiung Medical University","Kaohsiung Medical University Chung-Ho Memorial Hospital","Kaohsiung Medical University Research Center"],"pagination":["180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9074181"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. However, the link between immunodeficiency and prostate cancer progression remains unclear. Therefore, the aim of this study was to evaluate the effects of common genetic variants among eight immunodeficiency pathway-related genes on disease recurrence in prostate cancer patients treated with radical prostatectomy.<h4>Methods</h4>Genetic and bioinformatic analyses on 19 haplotype-tagging single-nucleotide polymorphisms in eight immunodeficiency pathway-related genes were conducted in 458 patients with prostate cancer after receiving radical prostatectomy. Furthermore, the TNFRSF13B was knocked down in 22Rv1 and PC-3 human prostate cance"],"journal":["Cancer cell international"],"pubmed_title":["TNFRSF13B is a potential contributor to prostate cancer."],"pmcid":["PMC9074181"],"funding_grant_id":["CMU110-MF-59","109-2320-B-037-007-MY3","NHRIKMU-111-I002","KMUH109-9R63, and KMUH109-9R64","108-2320-B-039-050-MY3","KMUH109-9R64","KMUH109-9R63","108-2314-B-037-029","KMU-TC108A04-4","CMU109-SR-64","109-2314-B-037-106-MY3","KMU-DK(A)111003","CMU109-MF-65","KMUH105-5R42","109-2314-B-037-108-MY2","KMUH108-8R55","108-2314-B-037-026-MY2","KMUH108-8R55, KMUH109-9R63, and KMUH109-9R64","KMUH108-8R53"],"pubmed_authors":["Wu HE","Huang SP","Li CY","Chen YT","Lin VC","Geng JH","Huang CY","Lu TL","Cheng WC","Bao BY","Yu CC"],"additional_accession":[]},"is_claimable":false,"name":"TNFRSF13B is a potential contributor to prostate cancer.","description":"<h4>Background</h4>Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. However, the link between immunodeficiency and prostate cancer progression remains unclear. Therefore, the aim of this study was to evaluate the effects of common genetic variants among eight immunodeficiency pathway-related genes on disease recurrence in prostate cancer patients treated with radical prostatectomy.<h4>Methods</h4>Genetic and bioinformatic analyses on 19 haplotype-tagging single-nucleotide polymorphisms in eight immunodeficiency pathway-related genes were conducted in 458 patients with prostate cancer after receiving radical prostatectomy. Furthermore, the TNFRSF13B was knocked down in 22Rv1 and PC-3 human prostate cance","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-31T07:02:58.711Z","creation":"2024-11-14T20:17:07.57Z"},"accession":"S-EPMC9074181","cross_references":{"pubmed":["35524261"],"doi":["10.1186/s12935-022-02590-2"]}}