{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Forshaw S"],"funding":["Engineering and Physical Sciences Research Council"],"pagination":["36154-36161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9074932"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(62)"],"pubmed_abstract":["We report the synthesis of a bipyridyl reagent containing a strained alkyne, which significantly restricts its flexibility. Upon strain-promoted alkyne-azide cycloaddition (SPAAC) with an azide, which does not require a Cu catalyst, the structure becomes significantly more flexible and an increase in fluorescence is observed. Upon addition of Zn(ii), the fluorescence is enhanced further. The reagent has the potential to act as a fluorescent labelling agent with azide-containing substrates, including biological molecules."],"journal":["RSC advances"],"pubmed_title":["A strained alkyne-containing bipyridine reagent; synthesis, reactivity and fluorescence properties."],"pmcid":["PMC9074932"],"funding_grant_id":["EP/M006670/1","1938254"],"pubmed_authors":["Wills M","Forshaw S","Chmel NP","Knighton RC","Parker JS","Reber J"],"additional_accession":[]},"is_claimable":false,"name":"A strained alkyne-containing bipyridine reagent; synthesis, reactivity and fluorescence properties.","description":"We report the synthesis of a bipyridyl reagent containing a strained alkyne, which significantly restricts its flexibility. Upon strain-promoted alkyne-azide cycloaddition (SPAAC) with an azide, which does not require a Cu catalyst, the structure becomes significantly more flexible and an increase in fluorescence is observed. Upon addition of Zn(ii), the fluorescence is enhanced further. The reagent has the potential to act as a fluorescent labelling agent with azide-containing substrates, including biological molecules.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-26T04:41:50.256Z","creation":"2025-04-06T11:13:17.895Z"},"accession":"S-EPMC9074932","cross_references":{"pubmed":["35540623"],"doi":["10.1039/c9ra06866j"]}}