biostudies-literatureLyu XLNational Basic Research Program of ChinaNational Natural Science Foundation of China36213-36216https://www.ebi.ac.uk/biostudies/studies/S-EPMC9074944biostudies-literatureUnknown9(62)Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) smoothly gave the corresponding acetalation products. This mild protocol has potential utility for the synthesis of aldehydes by further protonization.RSC advancesBlue light photoredox-catalysed acetalation of alkynyl bromides.PMC90749442167211721772102217320022018YFD0200100Song HJHuang SSLyu XLWang QMLiu YXfalseBlue light photoredox-catalysed acetalation of alkynyl bromides.Herein, we report an organo-photoredox-based protocol using 2,2-diethoxyacetic acid as the acetal source to achieve acetalation of alkynyl bromides to afford various alkynyl acetal products. In addition to arylethynyl bromides, substrates bearing heteroaryl rings (thiophene, pyridine, and indole) smoothly gave the corresponding acetalation products. This mild protocol has potential utility for the synthesis of aldehydes by further protonization.2019-01-01T00:00:00Z2019 Nov2025-04-26T04:33:03.867Z2025-04-06T11:14:12.431ZS-EPMC90749443554061710.1039/c9ra06596b