biostudies-literatureMorningstar JENCATS NIH HHSNCRR NIH HHSNHLBI NIH HHSNIGMS NIH HHSe022332https://www.ebi.ac.uk/biostudies/studies/S-EPMC9075228biostudies-literatureUnknown10(24)Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP. Methods and Results We performed histopathologic analysis of left ventricular (LV) biopsies from peripapillary regions, inferobasal LV wall and apex on surgical patients with MVP, as well as in a mouse model of human MVP (<i>Dzip1^S14R</i><i>^/+</i>). Tension-dependent molecular pathways were subsequently assessed using both computational modeling and cyclicaJournal of the American Heart AssociationMitral Valve Prolapse Induces Regionalized Myocardial Fibrosis.PMC9075228UL1 TR001450T32 HL007260T32 GM132055P20 GM103444R01 HL149696F31 HL142159C06 RR018823F31 HL152494R35 HL161237R25 GM113278R01 HL131546R01 HL141855Bertrand PPoelzing SNorris RAWang CFulmer DSieg FMoore RWatts KSpampinato RAGensemer CGlover JGourdie RGMoore KBorger MAGuo LRichardson WJMorningstar JENagata YBeck TCLevine RAfalseMitral Valve Prolapse Induces Regionalized Myocardial Fibrosis.Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association with sudden cardiac death. These data combined with evidence for postrepair ventricular dysfunction in surgical patients with MVP support a link between fibrosis and MVP. Methods and Results We performed histopathologic analysis of left ventricular (LV) biopsies from peripapillary regions, inferobasal LV wall and apex on surgical patients with MVP, as well as in a mouse model of human MVP (<i>Dzip1^S14R</i><i>^/+</i>). Tension-dependent molecular pathways were subsequently assessed using both computational modeling and cyclica2021-01-01T00:00:00Z2021 Dec2026-06-04T04:38:36.759Z2025-04-04T07:47:07.232ZS-EPMC90752283487392410.1161/JAHA.121.022332