biostudies-literatureUnknown10(23)Guo XJBackground Atrial fibrillation (AF) is the most common form of clinical cardiac dysrhythmia responsible for thromboembolic cerebral stroke, congestive heart failure, and death. Aggregating evidence highlights the strong genetic basis of AF. Nevertheless, AF is of pronounced genetic heterogeneity, and in an overwhelming majority of patients, the genetic determinants underpinning AF remain elusive. Methods and Results By genome-wide screening with polymorphic microsatellite markers and linkage analysis in a 4-generation Chinese family affected with autosomal-dominant AF, a novel locus for AF was mapped to chromosome 1q24.2-q25.1, a 3.20-cM (≈4.19 Mbp) interval between markers D1S2851 and D1S218, with the greatest 2-point logarithm of odds score of 4.8165 for the marker D1S452 at recombinatioJournal of the American Heart Associatione023517https://www.ebi.ac.uk/biostudies/studies/S-EPMC9075371biostudies-literaturePRRX1 Loss-of-Function Mutations Underlying Familial Atrial Fibrillation.PMC9075371Ke ZPGuo YHQiu XBDi RMXu YJYang YQGuo XJYang CXWang JLi LSun YMGao RFfalsePRRX1 Loss-of-Function Mutations Underlying Familial Atrial Fibrillation.Background Atrial fibrillation (AF) is the most common form of clinical cardiac dysrhythmia responsible for thromboembolic cerebral stroke, congestive heart failure, and death. Aggregating evidence highlights the strong genetic basis of AF. Nevertheless, AF is of pronounced genetic heterogeneity, and in an overwhelming majority of patients, the genetic determinants underpinning AF remain elusive. Methods and Results By genome-wide screening with polymorphic microsatellite markers and linkage analysis in a 4-generation Chinese family affected with autosomal-dominant AF, a novel locus for AF was mapped to chromosome 1q24.2-q25.1, a 3.20-cM (≈4.19 Mbp) interval between markers D1S2851 and D1S218, with the greatest 2-point logarithm of odds score of 4.8165 for the marker D1S452 at recombinatio2021-01-01T00:00:00Z2021 Dec2025-04-04T10:01:43.397Z2025-04-04T10:01:43.397ZS-EPMC90753713484593310.1161/JAHA.121.023517