{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lind L"],"funding":["NIDDK NIH HHS"],"pagination":["e023330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9075402"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(23)"],"pubmed_abstract":["Background We recently reported a link between plasma levels of 2 of 84 cardiovascular disease (CVD)-related proteins and the 3 major CVDs, myocardial infarction, ischemic stroke, and heart failure. The present study investigated whether measurement of almost 10 times the number of proteins could lead to discovery of additional risk markers for CVD. Methods and Results We measured 742 proteins using the proximity extension assay in 826 male participants of ULSAM (Uppsala Longitudinal Study of Adult Men) who were free from CVD at the age of 70 years. Cox proportional hazards models were adjusted for age only, as well as all traditional risk factors. During a 12.5-year median follow-up (maximal, 22.0 years), 283 incident CVDs occurred. Forty-one proteins were significantly (false discovery r"],"journal":["Journal of the American Heart Association"],"pubmed_title":["Large-Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure."],"pmcid":["PMC9075402"],"funding_grant_id":["R01 DK114183"],"pubmed_authors":["Lind L","Gustafsson S","Assimes TL","Arnlov J","Ingelsson M","Zanetti D"],"additional_accession":[]},"is_claimable":false,"name":"Large-Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure.","description":"Background We recently reported a link between plasma levels of 2 of 84 cardiovascular disease (CVD)-related proteins and the 3 major CVDs, myocardial infarction, ischemic stroke, and heart failure. The present study investigated whether measurement of almost 10 times the number of proteins could lead to discovery of additional risk markers for CVD. Methods and Results We measured 742 proteins using the proximity extension assay in 826 male participants of ULSAM (Uppsala Longitudinal Study of Adult Men) who were free from CVD at the age of 70 years. Cox proportional hazards models were adjusted for age only, as well as all traditional risk factors. During a 12.5-year median follow-up (maximal, 22.0 years), 283 incident CVDs occurred. Forty-one proteins were significantly (false discovery r","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T10:02:25.265Z","creation":"2025-04-04T10:02:25.265Z"},"accession":"S-EPMC9075402","cross_references":{"pubmed":["34845919"],"doi":["10.1161/JAHA.121.023330"]}}