{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Taub MA"],"funding":["BLRD VA","NCATS NIH HHS","NICHD NIH HHS","NCRR NIH HHS","NIA NIH HHS","NIEHS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIDDK NIH HHS","NHGRI NIH HHS","NCI NIH HHS","NINDS NIH HHS","NIAMS NIH HHS","NIH HHS","NIGMS NIH HHS"],"pagination":["S2666-979X(21)00105-1"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9075703"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(1)"],"pubmed_abstract":["Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value <5×10<sup>-9</sup>) in 36 loci associated with telomere length, including 20 newly associated loci (13 were replicated in external datasets). There was little evidence of effect size heterogeneity across "],"journal":["Cell genomics"],"pubmed_title":["Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed."],"pmcid":["PMC9075703"],"funding_grant_id":["R01 HL132523","R37 HL066289","R01 HL143818","UG1 HL139054","RC2 GM092618","R01 HL071205","R01 HL113323","R01 HL092301","R01 HL113326","R01 HL056177","R01 HL117004","U01 HL089897","R01 HL068959","U01 HL065962","OT3 HL142481","UM1 HL098123","R01 HL067348","U01 HL072496","P01 AI148104","OT3 HL142480","UM1 HL128711","R01 DK113003","U01 HG004798","R01 HL133221","R01 HL120393","R01 HL071051","HHSN268200800007C","R01 NS032830","U10 HL064295","R01 HL121007","UH3 OD023282","U01 HL072524","R01 HL104608","R01 HL112064","U10 HL098112","R01 HL095080","R01 ES021801","U01 HL157004","UM1 HL098147","R01 HL093093","U01 HL080295","R01 HL117626","R03 HL154284","P30 AG028747","R01 HL111249","R01 AR048797","N01 HC025195","UL1 RR024975","R01 HL113264","R01 DK071891","P01 HL045522","R01 HL080467","S10 RR025141","I01 BX005295","UL1 TR002243","U01 HL054457","R01 HL079915","R01 HL073410","R01 HL097163","OT3 HL142478","R01 HL118267","OT3 HL142479","P50 GM115305","R01 HL068986","R25 GM062459","U01 HL130114","U10 HL064307","R01 AG058921","N01 HC085083","N01 HC085082","R01 HL104135","N01 HC085081","HHSN268201500014C","U01 HL054464","N01 HC085086","U10 HL064305","N01 HC085080","R01 HL055673","R01 HL090682","R01 HL089856","R01 HL080083","R01 HL091889","R01 HL092217","R01 HL066216","U01 HL089856","R01 HL141845","T32 HG000040","R01 HL085251","U01 HL117721","UM1 HL098162","K01 HL135405","R01 HL071259","UH3 HL151865","R01 HL071258","75N92021D00006","U01 HG006378","S10 OD017985","UL1 TR000445","R01 HL092577","R01 HL071250","HHSN268201800001C","U01 AI126614","R01 HL087660","U01 HL054472","UM1 HG008895","R01 HL087263","U19 HL065962","P01 ES011627","U10 HL064288","U01 HL054527","UM1 HL128761","U10 HL064287","U01 HL072518","HHSN268201200036C","R01 HL119443","U01 HL054481","R01 HL046380","U01 HL130045","OT3 HL147154","R01 HL087698","R01 HL157635","R01 NS058700","U10 HL064313","N01 HC095159","R01 HL113338","U01 HL072507","R35 HL135818","UG3 OD023282","RC1 HL099355","N01 HC085079","U10 HL109164","R01 HD074711","R01 HL133040","U19 CA203654","R01 HL069234","U10 HL054472"],"pubmed_authors":["Cupples LA","Yang IV","Schwartz DA","Psaty BM","Pankratz N","Bowden DW","Burchard EG","Darbar D","Guo X","Sinner MF","Thornton T","Lane J","Taylor JG","Sheu WH","Wiggins KL","de las Fuentes L","TOPMed Hematology and Hemostasis Working Group","Tracy RP","Tiwari HK","Reupena MS","Nekhai S","Loos RJ","He J","Garrett ME","Battle A","Ellinor PT","Jain D","Levin AM","Redline S","Williams LK","Fingerlin TE","Shoemaker MB","Taub MA","Sciurba F","Levy D","Miller-Fleming TW","Johnsen JM","Yanek LR","Becker LC","Irvin MR","Kelly S","Kardia SL","Mak AC","Lee J","Zhao W","Blangero J","Correa A","Naseri T","Silverman EK","Montgomery CG","Hwang SJ","Conomos MP","Minster RL","Gogarten SM","Seidman C","Cox NJ","Raby BA","NHLBI CARE Network","de Andrade M","Smith AV","Sabino EC","Smith JA","Taylor KD","Kaplan R","Reiner AP","McHugh CP","Arvanitis M","Blackwell TW","Su JL","Laurie CC","Nouraie M","Laurie CA","Meyers DA","Heckbert SR","Roden D","Palmer ND","Bis JC","Celedon JC","Mathias RA","Custer B","Kooperberg C","Aviv A","Hidalgo BA","TOPMed Structural Variation Working Group","Launer L","Mitchell BD","McGarvey ST","Rotter JI","Boerwinkle E","Rich SS","Iyer KR","Weinstock JS","Kumar R","Wilson JG","Rafaels N","Chen Z","Curran JE","Barwick L","Telen MJ","Gui H","Eng C","Wen F","Abecasis G","Auer PL","Vasan RS","Keener R","Raffield LM","Gilliland FD","Freedman BI","Kenny EE","Weeks DE","Cho MH","Chang YPC","Brody JA","O'Connell J","Peyser PA","Aslibekyan S","Gelb BD","Fornage M","DeMeo DL","Peralta JM","Keramati A","Heavner B","Islam T","Ashley-Koch AE","Moscati A","Daya M","Liu S","Smith NL","Weiss ST","White MJ","Ruczinski I","Gladwin MT","Arnett DK","Armanios M","Johnson WC","Deka R","Bleecker ER","Wheeler MM","Perry JA","Nickerson DA","Hou L","Cade BE","Kaab S","Zhang Y","Konkle BA","NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium","Chen YI","Barnes KC","Liu C","North KE"],"additional_accession":[]},"is_claimable":false,"name":"Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.","description":"Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value <5×10<sup>-9</sup>) in 36 loci associated with telomere length, including 20 newly associated loci (13 were replicated in external datasets). There was little evidence of effect size heterogeneity across ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-05-09T19:46:47.148Z","creation":"2025-08-18T09:53:23.733Z"},"accession":"S-EPMC9075703","cross_references":{"pubmed":["35530816"],"doi":["10.1016/j.xgen.2021.100084"]}}