{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jain R"],"funding":["Department of Biotechnology, Ministry of Science and Technology"],"pagination":["38745-38759"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9075944"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(66)"],"pubmed_abstract":["Synthetic bioactive hydrogels have been widely recognized as key elements of emerging strategies for tissue engineering. The complex hierarchical structure and chemical composition of the natural ECM inspires us to design multi-component ECM mimics that have potential applications in biomedicine. Taking inspiration from natural proteins, we hypothesized that designing a multi-component synthetic matrix based on short ECM derived peptides will be highly beneficial for providing a functional scaffold, which still remains a challenge in the field of biomaterials. For the proof of concept, we designed a composite hydrogel scaffold inspired by the two essential components of native ECM, <i>i.e.</i> collagen and laminin, which play diverse roles in supporting cell growth. To the best of our know"],"journal":["RSC advances"],"pubmed_title":["Designing a bioactive scaffold from coassembled collagen-laminin short peptide hydrogels for controlling cell behaviour."],"pmcid":["PMC9075944"],"funding_grant_id":["BT/PR22067/NNT/28/1163/2016"],"pubmed_authors":["Jain R","Roy S"],"additional_accession":[]},"is_claimable":false,"name":"Designing a bioactive scaffold from coassembled collagen-laminin short peptide hydrogels for controlling cell behaviour.","description":"Synthetic bioactive hydrogels have been widely recognized as key elements of emerging strategies for tissue engineering. The complex hierarchical structure and chemical composition of the natural ECM inspires us to design multi-component ECM mimics that have potential applications in biomedicine. Taking inspiration from natural proteins, we hypothesized that designing a multi-component synthetic matrix based on short ECM derived peptides will be highly beneficial for providing a functional scaffold, which still remains a challenge in the field of biomaterials. For the proof of concept, we designed a composite hydrogel scaffold inspired by the two essential components of native ECM, <i>i.e.</i> collagen and laminin, which play diverse roles in supporting cell growth. To the best of our know","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov","modification":"2025-04-19T07:28:02.522Z","creation":"2024-11-08T13:03:49.173Z"},"accession":"S-EPMC9075944","cross_references":{"pubmed":["35540202"],"doi":["10.1039/c9ra07454f"]}}