{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang JY"],"funding":["Sichuan Agricultural University","National Natural Science Foundation of China"],"pagination":["40462-40470"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9076260"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(69)"],"pubmed_abstract":["This study aimed to determine whether hydroxy-analogue of selenomethionine (HMSeBA) supplementation could alleviate LPS-induced immunological stress in mice. A total of 90 Kunming mice were randomly assigned into 5 groups. The CON-LPS and CON+LPS groups were fed basal diet (BD), the others were fed BD with different levels of HMSeBA (0.15, 0.30 and 0.45 mg Se per kg) for 4 weeks. Mice were injected with LPS (3 mg per kg BW) or the corresponding physiological saline at 14 d and 28 d. Plasma and spleens were collected at 28 d. The results showed that: (1) LPS injection decreased ADG of mice at the 3<sup>rd</sup> week, and increased the concentration of IL-6 and TNF-α in plasma and the spleen index; (2) LPS injection induced immunological stress, up-regulated 8 inflammation-related genes and "],"journal":["RSC advances"],"pubmed_title":["The hydroxy-analogue of selenomethionine alleviated lipopolysaccharide-induced inflammatory responses is associated with recover expression of several selenoprotein encoding genes in the spleens of Kunming mice."],"pmcid":["PMC9076260"],"funding_grant_id":["31772643","31272468","03570126"],"pubmed_authors":["Shang HY","Wang LQ","Liu GM","Tian G","Tang JY","Jia G","Chen XL","Cai JY","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"The hydroxy-analogue of selenomethionine alleviated lipopolysaccharide-induced inflammatory responses is associated with recover expression of several selenoprotein encoding genes in the spleens of Kunming mice.","description":"This study aimed to determine whether hydroxy-analogue of selenomethionine (HMSeBA) supplementation could alleviate LPS-induced immunological stress in mice. A total of 90 Kunming mice were randomly assigned into 5 groups. The CON-LPS and CON+LPS groups were fed basal diet (BD), the others were fed BD with different levels of HMSeBA (0.15, 0.30 and 0.45 mg Se per kg) for 4 weeks. Mice were injected with LPS (3 mg per kg BW) or the corresponding physiological saline at 14 d and 28 d. Plasma and spleens were collected at 28 d. The results showed that: (1) LPS injection decreased ADG of mice at the 3<sup>rd</sup> week, and increased the concentration of IL-6 and TNF-α in plasma and the spleen index; (2) LPS injection induced immunological stress, up-regulated 8 inflammation-related genes and ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-04T23:16:46.046Z","creation":"2025-02-19T03:24:12.256Z"},"accession":"S-EPMC9076260","cross_references":{"pubmed":["35542664"],"doi":["10.1039/c9ra07260h"]}}