{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(71)"],"submitter":["Li J"],"funding":["Natural Sciences and Engineering Research Council of Canada","National Research Council Canada"],"pubmed_abstract":["Bis-(3'-5')-cyclic dimeric 2'-deoxy-2'-fluoroguanosine monophosphate (2'-F-c-di-GMP) was synthesized through the modified H-phosphonate chemistry. Oral immunization of C57BL/6 mice with <i>Helicobacter pylori</i> cell-free sonicate extract adjuvanted with 2'-F-c-di-GMP led to the production of antigen-specific antibodies in feces and sera, and lowered bacterial counts in the stomach upon post-vaccination infections in immunized mice. Similarly, oral vaccination of BALB/c mice with flagillin proteins from <i>Clostridium difficile</i> and <i>Listeria monocytogenes</i> adjuvanted with 2'-F-c-di-GMP led to production of antigen-specific antibodies both systemically and mucosally. The adjuvanticity of 2'-F-c-di-GMP is associated with the enhanced induction of interferon γ. These results demonst"],"journal":["RSC advances"],"pagination":["41481-41489"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9076492"],"repository":["biostudies-literature"],"pubmed_title":["2'-Fluoro-c-di-GMP as an oral vaccine adjuvant."],"pmcid":["PMC9076492"],"pubmed_authors":["Li J","Lee RK","Chen W","Yan H"],"additional_accession":[]},"is_claimable":false,"name":"2'-Fluoro-c-di-GMP as an oral vaccine adjuvant.","description":"Bis-(3'-5')-cyclic dimeric 2'-deoxy-2'-fluoroguanosine monophosphate (2'-F-c-di-GMP) was synthesized through the modified H-phosphonate chemistry. Oral immunization of C57BL/6 mice with <i>Helicobacter pylori</i> cell-free sonicate extract adjuvanted with 2'-F-c-di-GMP led to the production of antigen-specific antibodies in feces and sera, and lowered bacterial counts in the stomach upon post-vaccination infections in immunized mice. Similarly, oral vaccination of BALB/c mice with flagillin proteins from <i>Clostridium difficile</i> and <i>Listeria monocytogenes</i> adjuvanted with 2'-F-c-di-GMP led to production of antigen-specific antibodies both systemically and mucosally. The adjuvanticity of 2'-F-c-di-GMP is associated with the enhanced induction of interferon γ. These results demonst","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-04T23:17:16.51Z","creation":"2024-10-19T04:03:42.781Z"},"accession":"S-EPMC9076492","cross_references":{"pubmed":["35541605"],"doi":["10.1039/c9ra08310c"]}}