{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li H"],"funding":["National Natural Science Foundation of China"],"pagination":["42163-42171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9076572"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(72)"],"pubmed_abstract":["Water-soluble NaYF<sub>4</sub>:Yb/Er@NaLuF<sub>4</sub>:Yb up-converting nanoparticles (UCNPs) with a strong green emission were successfully prepared by a solvothermal method in a short period of time and at a low temperature. First, the hydrophobic UCNPs were prepared by a simple solvothermal method, then modified using a polyetherimide (PEI) surfactant or oxidation of the oleic acid ligands with the Lemieux-von Rudloff reagent. The modified UCNPs, having an average particle diameter of 60 ± 5 nm, showed a high dispersity. The oleic acid ligand on the sample surface was oxidized azelaic acid (HOOC(CH<sub>2</sub>)<sub>7</sub>COOH), identified from Fourier transform infrared (FTIR) spectroscopy, which results in the generation of free carboxylic acid, hence conferring a high solubility in water. The 3-4,5-dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide (MTT) method and cell-targeted labeling proved that oleic acid-capped UCNPs after oxidation (UCNPs-OAO) have a higher biocompatibility than polyetherimide-capped UCNPs (UCNPs-PEI). Therefore, the UCNPs-OAO have a great potential in biomedical applications, such as multimodal imaging, targeted therapy, and gene therapy."],"journal":["RSC advances"],"pubmed_title":["Solvothermal synthesis and modification of NaYF<sub>4</sub>:Yb/Er@NaLuF<sub>4</sub>:Yb for enhanced up-conversion luminescence for bioimaging."],"pmcid":["PMC9076572"],"funding_grant_id":["51372127"],"pubmed_authors":["Liu X","Li H","Li X"],"additional_accession":[]},"is_claimable":false,"name":"Solvothermal synthesis and modification of NaYF<sub>4</sub>:Yb/Er@NaLuF<sub>4</sub>:Yb for enhanced up-conversion luminescence for bioimaging.","description":"Water-soluble NaYF<sub>4</sub>:Yb/Er@NaLuF<sub>4</sub>:Yb up-converting nanoparticles (UCNPs) with a strong green emission were successfully prepared by a solvothermal method in a short period of time and at a low temperature. First, the hydrophobic UCNPs were prepared by a simple solvothermal method, then modified using a polyetherimide (PEI) surfactant or oxidation of the oleic acid ligands with the Lemieux-von Rudloff reagent. The modified UCNPs, having an average particle diameter of 60 ± 5 nm, showed a high dispersity. The oleic acid ligand on the sample surface was oxidized azelaic acid (HOOC(CH<sub>2</sub>)<sub>7</sub>COOH), identified from Fourier transform infrared (FTIR) spectroscopy, which results in the generation of free carboxylic acid, hence conferring a high solubility in water. The 3-4,5-dimethylthiazol-2-yl-2,5-diphenyl tetrazolium bromide (MTT) method and cell-targeted labeling proved that oleic acid-capped UCNPs after oxidation (UCNPs-OAO) have a higher biocompatibility than polyetherimide-capped UCNPs (UCNPs-PEI). Therefore, the UCNPs-OAO have a great potential in biomedical applications, such as multimodal imaging, targeted therapy, and gene therapy.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-04T20:50:17.023Z","creation":"2025-02-19T03:25:13.777Z"},"accession":"S-EPMC9076572","cross_references":{"pubmed":["35542885"],"doi":["10.1039/c9ra08921g"]}}