{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang J"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["440"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9076672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to β-cell failure. Oxidative stress is an important risk factor for PSC activation. There is no direct evidence proving if administration of glutathione can inhibit fibrosis and β-cell failure. To explore the role of glutathione in pancreatic fibrosis and β-cell failure induced by hyperglycaemia, we established a rat model of pancreatic fibrosis and β-cell failure. The model was founded through long-term oscillating glucose (LOsG) intake and the setup of a sham group and a glutathione intervention group. In vitro, rat PSCs were treated with low glucose, high glucose, or high glucose plus glutathione to explore the mechanism of high glucose-induced PSC activation and the downstream"],"journal":["Cell death & disease"],"pubmed_title":["Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway."],"pmcid":["PMC9076672"],"funding_grant_id":["82070855"],"pubmed_authors":["Zhou Q","Hu Y","Wang Q","Yang L","Zhang J","Zhou C","An H","Bai J","Chen H","Chen X","Wang Y","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway.","description":"The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to β-cell failure. Oxidative stress is an important risk factor for PSC activation. There is no direct evidence proving if administration of glutathione can inhibit fibrosis and β-cell failure. To explore the role of glutathione in pancreatic fibrosis and β-cell failure induced by hyperglycaemia, we established a rat model of pancreatic fibrosis and β-cell failure. The model was founded through long-term oscillating glucose (LOsG) intake and the setup of a sham group and a glutathione intervention group. In vitro, rat PSCs were treated with low glucose, high glucose, or high glucose plus glutathione to explore the mechanism of high glucose-induced PSC activation and the downstream","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-26T04:43:14.412Z","creation":"2025-02-19T03:27:27.709Z"},"accession":"S-EPMC9076672","cross_references":{"pubmed":["35523788"],"doi":["10.1038/s41419-022-04894-7"]}}