biostudies-literatureUnknown128(5)Maulana MINWO domain Applied and Engineering Sciences VENI grantMost ectotherms obey the temperature-size rule, meaning they grow larger in a colder environment. This raises the question of how the interplay between genes and temperature affects the body size of ectotherms. Despite the growing body of literature on the physiological life-history and molecular genetic mechanism underlying the temperature-size rule, the overall genetic architecture orchestrating this complex phenotype is not yet fully understood. One approach to identify genetic regulators of complex phenotypes is quantitative trait locus (QTL) mapping. Here, we explore the genetic architecture of body-size phenotypes, and plasticity of body-size phenotypes at different temperatures using Caenorhabditis elegans as a model ectotherm. We used 40 recombinant inbred lines (RILs) derived fromHeredity313-324https://www.ebi.ac.uk/biostudies/studies/S-EPMC9076863biostudies-literatureThe genetic architecture underlying body-size traits plasticity over different temperatures and developmental stages in Caenorhabditis elegans.PMC9076863Riksen JAGMaulana MISterken MGKammenga JESnoek BLfalseThe genetic architecture underlying body-size traits plasticity over different temperatures and developmental stages in Caenorhabditis elegans.Most ectotherms obey the temperature-size rule, meaning they grow larger in a colder environment. This raises the question of how the interplay between genes and temperature affects the body size of ectotherms. Despite the growing body of literature on the physiological life-history and molecular genetic mechanism underlying the temperature-size rule, the overall genetic architecture orchestrating this complex phenotype is not yet fully understood. One approach to identify genetic regulators of complex phenotypes is quantitative trait locus (QTL) mapping. Here, we explore the genetic architecture of body-size phenotypes, and plasticity of body-size phenotypes at different temperatures using Caenorhabditis elegans as a model ectotherm. We used 40 recombinant inbred lines (RILs) derived from2022-01-01T00:00:00Z2022 May2025-04-28T07:11:26.005Z2025-04-06T19:17:09.536ZS-EPMC90768633538331710.1038/s41437-022-00528-y