biostudies-literatureXu BNatural Science Foundation of ShanghaiNational Natural Science Foundation of China1265-1273https://www.ebi.ac.uk/biostudies/studies/S-EPMC9076948biostudies-literatureUnknown8(3)The high efficiency and specificity of gene therapy are mainly ascribed to the excellent transfection ability of the gene carrier. Non-viral polymer vectors have attracted extensive attention because of their low cytotoxicity and outstanding genetic loading capacity compared with viral vectors. For safe and efficient transfection of nuclear acids, here we report a novel gene delivery system, dendrimer-entrapped gold nanoparticles modified with a folate-conjugated poly (ethylene glycol) (Au DENPs-PEG-FA), possessing superior gene transfection efficiency than that of partially hydrophilic methoxy poly(ethylene glycol) (mPEG)-modified dendrimer-entrapped gold nanoparticles (Au DENPs-mPEG). The prepared Au DENPs-PEG-FA were well characterized, and our data revealed that the vector showed good RSC advancesPEGylated dendrimer-entrapped gold nanoparticles with low immunogenicity for targeted gene delivery.PMC9076948314008168176114802817ZR140120021773026Cao XXu BLi AHao XGuo RShi XfalsePEGylated dendrimer-entrapped gold nanoparticles with low immunogenicity for targeted gene delivery.The high efficiency and specificity of gene therapy are mainly ascribed to the excellent transfection ability of the gene carrier. Non-viral polymer vectors have attracted extensive attention because of their low cytotoxicity and outstanding genetic loading capacity compared with viral vectors. For safe and efficient transfection of nuclear acids, here we report a novel gene delivery system, dendrimer-entrapped gold nanoparticles modified with a folate-conjugated poly (ethylene glycol) (Au DENPs-PEG-FA), possessing superior gene transfection efficiency than that of partially hydrophilic methoxy poly(ethylene glycol) (mPEG)-modified dendrimer-entrapped gold nanoparticles (Au DENPs-mPEG). The prepared Au DENPs-PEG-FA were well characterized, and our data revealed that the vector showed good 2018-01-01T00:00:00Z2018 Jan2025-04-04T23:15:44.267Z2025-04-04T23:15:44.267ZS-EPMC90769483554088410.1039/c7ra11901a