{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["Chinese Academy of Sciences","National Natural Science Foundation of China"],"pagination":["1677-1685"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9077091"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(3)"],"pubmed_abstract":["Brain organoids derived from the self-organization of human induced pluripotent stem cells (hiPSCs) represent a new class of <i>in vitro</i> organ system for modeling brain development and diseases. However, engineering brain organoids in a biomimetic environment that is favorable for brain development remains challenging. In this work, we present a new strategy to generate hiPSCs-derived 3D brain organoids using an organ-on-a-chip system in a controlled manner. This system provides a biomimetic brain microenvironment by incorporating three-dimensional (3D) Matrigel, fluid flow and multicellular architectures of tissues that allows for extended 3D culture, <i>in situ</i> neural differentiation, and organization of brain organoids on a single device. The generated brain organoids display we"],"journal":["RSC advances"],"pubmed_title":["Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system."],"pmcid":["PMC9077091"],"funding_grant_id":["31671038","31600784","81573394","XDA16020900","91543121","XDPB0305"],"pubmed_authors":["Guo Y","Zhu Y","Qin J","Wang Y","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system.","description":"Brain organoids derived from the self-organization of human induced pluripotent stem cells (hiPSCs) represent a new class of <i>in vitro</i> organ system for modeling brain development and diseases. However, engineering brain organoids in a biomimetic environment that is favorable for brain development remains challenging. In this work, we present a new strategy to generate hiPSCs-derived 3D brain organoids using an organ-on-a-chip system in a controlled manner. This system provides a biomimetic brain microenvironment by incorporating three-dimensional (3D) Matrigel, fluid flow and multicellular architectures of tissues that allows for extended 3D culture, <i>in situ</i> neural differentiation, and organization of brain organoids on a single device. The generated brain organoids display we","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2025-04-04T20:50:49.75Z","creation":"2025-02-19T03:24:57.996Z"},"accession":"S-EPMC9077091","cross_references":{"pubmed":["35540867"],"doi":["10.1039/c7ra11714k"]}}