biostudies-literatureUnknown8(5)Tran CBAn efficient protocol for 8-aminoquinoline assisted alkoxylation and phenoxylation of sp<sup>2</sup> C-H bonds under heterogeneous catalysis was developed. The optimal conditions employed Cu-MOF-74 (20%), K<sub>2</sub>CO<sub>3</sub> base, pyridine ligand or dimethyl formamide solvent, and O<sub>2</sub> oxidant at 80 °C or 100 °C for 24 hours. Cu-MOF-74 revealed remarkably higher activity when compared with other previously commonly used Cu-MOFs in cross coupling reactions, supported copper catalysts, and homogeneous copper salts. The reaction scope with respect to coupling partners included a wide range of various substrates. Interestingly, the developed conditions are applicable for the synthesis of high-profile relevant biological agents from easily accessible starting materials. FurtherRSC advances2829-2836https://www.ebi.ac.uk/biostudies/studies/S-EPMC9077472biostudies-literatureAuxiliary-directed etherification of sp<sup>2</sup> C-H bonds under heterogeneous metal-organic framework catalysis: synthesis of ethenzamide.PMC9077472Cao TTVLu HDTran CBTruong TDuong XNTfalseAuxiliary-directed etherification of sp<sup>2</sup> C-H bonds under heterogeneous metal-organic framework catalysis: synthesis of ethenzamide.An efficient protocol for 8-aminoquinoline assisted alkoxylation and phenoxylation of sp<sup>2</sup> C-H bonds under heterogeneous catalysis was developed. The optimal conditions employed Cu-MOF-74 (20%), K<sub>2</sub>CO<sub>3</sub> base, pyridine ligand or dimethyl formamide solvent, and O<sub>2</sub> oxidant at 80 °C or 100 °C for 24 hours. Cu-MOF-74 revealed remarkably higher activity when compared with other previously commonly used Cu-MOFs in cross coupling reactions, supported copper catalysts, and homogeneous copper salts. The reaction scope with respect to coupling partners included a wide range of various substrates. Interestingly, the developed conditions are applicable for the synthesis of high-profile relevant biological agents from easily accessible starting materials. Further2018-01-01T00:00:00Z2018 Jan2025-04-04T09:10:18.157Z2025-02-19T03:24:32.275ZS-EPMC90774723554149910.1039/c7ra12010a