biostudies-literatureUnknown8(6)Tang CKA catalytic asymmetric method for the synthesis of polysubstituted chromans <i>via</i> an oxa-Michael-nitro-Michael reaction has been developed. The squaramide-catalyzed domino reaction of 2-hydroxynitrostyrenes with <i>trans</i>-β-nitroolefins produced chiral chromans with excellent enantioselectivities (up to 99% ee), diastereoselectivities (up to >20 : 1 dr), and moderate to good yields (up to 82%).RSC advances3095-3098https://www.ebi.ac.uk/biostudies/studies/S-EPMC9077565biostudies-literatureAsymmetric synthesis of polysubstituted chiral chromans <i>via</i> an organocatalytic oxa-Michael-nitro-Michael domino reaction.PMC9077565Li CZheng YYTang CKXu DQFeng KXXia ABXu ZYfalseAsymmetric synthesis of polysubstituted chiral chromans <i>via</i> an organocatalytic oxa-Michael-nitro-Michael domino reaction.A catalytic asymmetric method for the synthesis of polysubstituted chromans <i>via</i> an oxa-Michael-nitro-Michael reaction has been developed. The squaramide-catalyzed domino reaction of 2-hydroxynitrostyrenes with <i>trans</i>-β-nitroolefins produced chiral chromans with excellent enantioselectivities (up to 99% ee), diastereoselectivities (up to >20 : 1 dr), and moderate to good yields (up to 82%).2018-01-01T00:00:00Z2018 Jan2024-11-15T13:04:46.885Z2024-11-15T13:04:46.885ZS-EPMC90775653554117310.1039/c7ra13525d