{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Axelrud LK"],"funding":["Intramural NIH HHS","NIBIB NIH HHS","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul","NIA NIH HHS","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","NIMH NIH HHS","Fundação de Amparo à Pesquisa do Estado de São Paulo","National Institute of Mental Health"],"pagination":["1895-1906"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9077631"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(12)"],"pubmed_abstract":["In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6-14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS were derived by summing the product of each standardized brain feature by the effect size of the association of that brain feature with seven psyc"],"journal":["European child & adolescent psychiatry"],"pubmed_title":["Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth."],"pmcid":["PMC9077631"],"funding_grant_id":["R01 MH120482","R56 AG058854","ZIA MH002781","U54 EB020403","R01 MH085772"],"pubmed_authors":["Martinot MLP","Pine DS","Jackowski A","Desrivieres S","Ittermann B","Orfanos DP","IMAGEN Consortium","Garavan H","Salum GA","Barker G","Barker GJ","Poustka L","Milham M","Smolka MN","Quinlan EB","Heinz A","Pan PM","Barker ED","Bokde ALW","Winkler AM","Hoexter MQ","Parker N","Martinot MP","Millenet S","Frohner JH","Zugman A","Hohmann S","Lemaitre H","Sato JR","Banaschewski T","Axelrud LK","Walter H","Flor H","Picon F","Satterthwaite T","Simioni AR","Whelan R","Rohde LA","Gowland P","Paus T","Nees F","Artiges E","Martinot JL","Grigis A","Schumann G"],"additional_accession":[]},"is_claimable":false,"name":"Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth.","description":"In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6-14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS were derived by summing the product of each standardized brain feature by the effect size of the association of that brain feature with seven psyc","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T14:49:27.502Z","creation":"2025-04-04T14:49:27.502Z"},"accession":"S-EPMC9077631","cross_references":{"pubmed":["33030612"],"doi":["10.1007/s00787-020-01653-x"]}}