biostudies-literatureUnknown8(6)He YA metal-free, mild and efficient protocol for the construction of aroylated N-heterocycles <i>via</i> radical cascade aroylation of phenyl or vinyl isocyanides with aromatic aldehydes has been developed. Both phenanthridine and isoquinoline derivatives are delivered quickly in moderate to good yields with high regioselectivity.RSC advances3036-3040https://www.ebi.ac.uk/biostudies/studies/S-EPMC9077706biostudies-literatureMetal-free oxidative isocyanides insertion with aromatic aldehydes to aroylated N-heterocycles.PMC9077706Gan CHuang CXiao JAHe YHuang YPang JWang XfalseMetal-free oxidative isocyanides insertion with aromatic aldehydes to aroylated N-heterocycles.A metal-free, mild and efficient protocol for the construction of aroylated N-heterocycles <i>via</i> radical cascade aroylation of phenyl or vinyl isocyanides with aromatic aldehydes has been developed. Both phenanthridine and isoquinoline derivatives are delivered quickly in moderate to good yields with high regioselectivity.2018-01-01T00:00:00Z2018 Jan2025-04-21T23:18:47Z2025-02-19T03:24:57.618ZS-EPMC90777063554117910.1039/c7ra12755c