biostudies-literatureMansfield EDHUniversity of ReadingScience and Technology Facilities Council6471-6478https://www.ebi.ac.uk/biostudies/studies/S-EPMC9078266biostudies-literatureUnknown8(12)Functionalising nanoparticles with polymers has gained much interest in recent years, as it aids colloidal stability and manipulation of surface properties. Here, polymer-coated thiolated silica nanoparticles were synthesised by self-condensation of 3-mercaptopropyltrimethoxysilane in the presence of hydroxyethylcellulose. These nanoparticles were characterised by dynamic light scattering, small angle neutron scattering, Nanoparticle Tracking Analysis, Raman spectroscopy, FT-IR spectroscopy, thermogravimetric analysis, Ellman's assay, transmission electron microscopy and cryo-transmission electron microscopy. It was found that increasing the amount of hydroxyethylcellulose in the reaction mixture increased the nanoparticle size and reduced the number of thiol groups on their surface. AdditRSC advancesStructure and characterisation of hydroxyethylcellulose-silica nanoparticles.PMC90782661320288Khutoryanskiy VVPandya YAbutbul-Ionita IDanino DRogers SEMansfield EDHWilliams ACMun EAfalseStructure and characterisation of hydroxyethylcellulose-silica nanoparticles.Functionalising nanoparticles with polymers has gained much interest in recent years, as it aids colloidal stability and manipulation of surface properties. Here, polymer-coated thiolated silica nanoparticles were synthesised by self-condensation of 3-mercaptopropyltrimethoxysilane in the presence of hydroxyethylcellulose. These nanoparticles were characterised by dynamic light scattering, small angle neutron scattering, Nanoparticle Tracking Analysis, Raman spectroscopy, FT-IR spectroscopy, thermogravimetric analysis, Ellman's assay, transmission electron microscopy and cryo-transmission electron microscopy. It was found that increasing the amount of hydroxyethylcellulose in the reaction mixture increased the nanoparticle size and reduced the number of thiol groups on their surface. Addit2018-01-01T00:00:00Z2018 Feb2025-04-22T01:42:36.441Z2024-10-19T03:57:24.592ZS-EPMC90782663554042510.1039/c7ra08716k