{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhuang Y"],"funding":["National Natural Science Foundation of China","Natural Science Foundation of Jiangsu Province"],"pagination":["8870-8877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9078587"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(16)"],"pubmed_abstract":["<i>Xanthii Fructus</i> (XF), a famous traditional Chinese medicine (TCM), has been widely used in the treatment of rhinitis and other diseases. However, the targets of the main XF components found in the blood after oral administration of XF extract are still unclear. In the current study, a feasible systems pharmacology method was developed to predict these targets. In accordance with our previous research, XF components were selected including cleomiscosin A, myristic acid, succinic acid, xanthosine, sitostenone, emodin, apigenin, and chrysophanol. Three components, namely emodin, apigenin, and chrysophanol, failed to be detected with target proteins, thus the other five components, namely cleomiscosin A, myristic acid, succinic acid, xanthosine and sitostenone, were eventually chosen fo"],"journal":["RSC advances"],"pubmed_title":["Prediction of the targets of the main components in blood after oral administration of <i>Xanthii Fructus</i>: a network pharmacology study."],"pmcid":["PMC9078587"],"funding_grant_id":["BK20161047","81573603"],"pubmed_authors":["Liu X","Cai B","Qin K","Yang B","Cai H","Zhuang Y"],"additional_accession":[]},"is_claimable":false,"name":"Prediction of the targets of the main components in blood after oral administration of <i>Xanthii Fructus</i>: a network pharmacology study.","description":"<i>Xanthii Fructus</i> (XF), a famous traditional Chinese medicine (TCM), has been widely used in the treatment of rhinitis and other diseases. However, the targets of the main XF components found in the blood after oral administration of XF extract are still unclear. In the current study, a feasible systems pharmacology method was developed to predict these targets. In accordance with our previous research, XF components were selected including cleomiscosin A, myristic acid, succinic acid, xanthosine, sitostenone, emodin, apigenin, and chrysophanol. Three components, namely emodin, apigenin, and chrysophanol, failed to be detected with target proteins, thus the other five components, namely cleomiscosin A, myristic acid, succinic acid, xanthosine and sitostenone, were eventually chosen fo","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2026-05-31T06:00:02.94Z","creation":"2025-04-20T00:21:14.575Z"},"accession":"S-EPMC9078587","cross_references":{"pubmed":["35539827"],"doi":["10.1039/c8ra00186c"]}}