{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiong Z"],"funding":["National Natural Science Foundation of China"],"pagination":["10023-10031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9078858"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(18)"],"pubmed_abstract":["Acute lung injury (ALI) is a severe respiratory disease. To date, no medical interventions have been proven effective in improving the outcome. Reduning injection (RDN) showed a potential effect in the therapy of ALI. However, seldom does research concern the holistic pharmacological mechanisms of RDN on ALI. A metabolomic strategy, based on two consecutive extractions of the lung tissue, has been developed to investigate therapeutic mechanisms of RDN on ALI model rat. The extraction procedure was an aqueous extraction with methanol-water followed by organic extraction with dichloromethane-methanol. According to the lipophilicity of extracts, aqueous extracts were analyzed on the T3 column and organic extracts on the C18 column. Partial least-squares discriminant analysis was utilized to i"],"journal":["RSC advances"],"pubmed_title":["Tissue metabolomic profiling to reveal the therapeutic mechanism of reduning injection on LPS-induced acute lung injury rats."],"pmcid":["PMC9078858"],"funding_grant_id":["81403062"],"pubmed_authors":["Lang L","Xiong Z","Ma S","Zhao L","Xiao W","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Tissue metabolomic profiling to reveal the therapeutic mechanism of reduning injection on LPS-induced acute lung injury rats.","description":"Acute lung injury (ALI) is a severe respiratory disease. To date, no medical interventions have been proven effective in improving the outcome. Reduning injection (RDN) showed a potential effect in the therapy of ALI. However, seldom does research concern the holistic pharmacological mechanisms of RDN on ALI. A metabolomic strategy, based on two consecutive extractions of the lung tissue, has been developed to investigate therapeutic mechanisms of RDN on ALI model rat. The extraction procedure was an aqueous extraction with methanol-water followed by organic extraction with dichloromethane-methanol. According to the lipophilicity of extracts, aqueous extracts were analyzed on the T3 column and organic extracts on the C18 column. Partial least-squares discriminant analysis was utilized to i","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-04T09:10:16.941Z","creation":"2025-02-19T03:24:32.192Z"},"accession":"S-EPMC9078858","cross_references":{"pubmed":["35540831"],"doi":["10.1039/c7ra13123b"]}}