{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(20)"],"submitter":["Liu N"],"pubmed_abstract":["The origin of complex hierarchical superstructures of biomaterials and their unique self-assembly mechanisms of formation are important in biological systems and have attracted considerable attention. In the present study, we investigated the morphological changes of calcium oxalate (CaO <sub><i>x</i></sub> ) crystals induced by additives including chiral aspartic acid, sodium citrate, Mg<sup>2+</sup>, casein and combinations of these molecules. The morphology and structure of CaO <sub><i>x</i></sub> were identified with the use of various techniques. The morphogenesis of CaO <sub><i>x</i></sub> crystals were significantly affected by chiral aspartic acid, sodium citrate or Mg<sup>2+</sup>. However, they only formed calcium oxalate monohydrate (COM). It was observed that the chiral aspartic acid, sodium citrate and casein adhered to the surface of the crystals. The adherence of Mg<sup>2+</sup> to crystals was not evident. Casein significantly affected the formation of COM and calcium oxalate dihydrate (COD). The ratio of different CaO <sub><i>x</i></sub> crystal forms is associated with the casein concentration. In combination with Mg<sup>2+</sup> or citrate ions, casein showed improved formation of COD. The present study mimics biomineralization with a simple chemical approach and provides insight into the complicated system of CaO <sub><i>x</i></sub> biomineralization as well as facilitates the understanding of urinary stone treatment."],"journal":["RSC advances"],"pagination":["11014-11020"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9078945"],"repository":["biostudies-literature"],"pubmed_title":["Shape and structure controlling of calcium oxalate crystals by a combination of additives in the process of biomineralization."],"pmcid":["PMC9078945"],"pubmed_authors":["Liu Z","Ping H","Guo J","Xie H","Tao F","Liu N","Wang L","Su BL"],"additional_accession":[]},"is_claimable":false,"name":"Shape and structure controlling of calcium oxalate crystals by a combination of additives in the process of biomineralization.","description":"The origin of complex hierarchical superstructures of biomaterials and their unique self-assembly mechanisms of formation are important in biological systems and have attracted considerable attention. In the present study, we investigated the morphological changes of calcium oxalate (CaO <sub><i>x</i></sub> ) crystals induced by additives including chiral aspartic acid, sodium citrate, Mg<sup>2+</sup>, casein and combinations of these molecules. The morphology and structure of CaO <sub><i>x</i></sub> were identified with the use of various techniques. The morphogenesis of CaO <sub><i>x</i></sub> crystals were significantly affected by chiral aspartic acid, sodium citrate or Mg<sup>2+</sup>. However, they only formed calcium oxalate monohydrate (COM). It was observed that the chiral aspartic acid, sodium citrate and casein adhered to the surface of the crystals. The adherence of Mg<sup>2+</sup> to crystals was not evident. Casein significantly affected the formation of COM and calcium oxalate dihydrate (COD). The ratio of different CaO <sub><i>x</i></sub> crystal forms is associated with the casein concentration. In combination with Mg<sup>2+</sup> or citrate ions, casein showed improved formation of COD. The present study mimics biomineralization with a simple chemical approach and provides insight into the complicated system of CaO <sub><i>x</i></sub> biomineralization as well as facilitates the understanding of urinary stone treatment.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-29T10:58:59.1Z","creation":"2024-10-15T07:28:38.161Z"},"accession":"S-EPMC9078945","cross_references":{"pubmed":["35541543"],"doi":["10.1039/c8ra00661j"]}}