{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(21)"],"submitter":["Zhang X"],"pubmed_abstract":["Liquiritin (LQ), the main bioactive constituent of licorice, is a common flavoring and sweetening agent in food products and has a wide range of pharmacological properties, including antidepressant-like, neuroprotective, anti-cancer and anti-inflammatory properties. This study investigated the metabolic pathways of LQ <i>in vitro</i> (rat liver microsomes) and <i>in vivo</i> (rat model) using ultra high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Moreover, supplementary tools such as key product ions (KPIs) were employed to search for and identify compounds. As a result, 56 <i>in vivo</i> metabolites and 15 <i>in vitro</i> metabolites were structurally characterized. Oxidation, reduction, hydrolysis, methylat"],"journal":["RSC advances"],"pagination":["11813-11827"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9079117"],"repository":["biostudies-literature"],"pubmed_title":["Identification of metabolites of liquiritin in rats by UHPLC-Q-TOF-MS/MS: metabolic profiling and pathway comparison <i>in vitro</i> and <i>in vivo</i>."],"pmcid":["PMC9079117"],"pubmed_authors":["Liang C","Zhang X","Zhang L","Sun Y","Yin J"],"additional_accession":[]},"is_claimable":false,"name":"Identification of metabolites of liquiritin in rats by UHPLC-Q-TOF-MS/MS: metabolic profiling and pathway comparison <i>in vitro</i> and <i>in vivo</i>.","description":"Liquiritin (LQ), the main bioactive constituent of licorice, is a common flavoring and sweetening agent in food products and has a wide range of pharmacological properties, including antidepressant-like, neuroprotective, anti-cancer and anti-inflammatory properties. This study investigated the metabolic pathways of LQ <i>in vitro</i> (rat liver microsomes) and <i>in vivo</i> (rat model) using ultra high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Moreover, supplementary tools such as key product ions (KPIs) were employed to search for and identify compounds. As a result, 56 <i>in vivo</i> metabolites and 15 <i>in vitro</i> metabolites were structurally characterized. Oxidation, reduction, hydrolysis, methylat","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-04T21:32:27.015Z","creation":"2025-04-04T21:32:27.015Z"},"accession":"S-EPMC9079117","cross_references":{"pubmed":["35542822"],"doi":["10.1039/c7ra13760e"]}}