biostudies-literatureUnknown8(21)Zhang HA novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D₂ <i>via</i> a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D₂ and could be monitored by cellular imaging.RSC advances11419-11423https://www.ebi.ac.uk/biostudies/studies/S-EPMC9079131biostudies-literatureA novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells.PMC9079131Fang ZZhang HfalseA novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells.A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D₂ <i>via</i> a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D₂ and could be monitored by cellular imaging.2018-01-01T00:00:00Z2018 Mar2025-04-18T14:14:08.216Z2025-02-19T03:25:28.674ZS-EPMC90791313554277110.1039/c8ra00271a