biostudies-literatureUnknown40Hagens MJ<h4>Context</h4>Systematic biopsies are additionally recommended to maximize the diagnostic performance of the magnetic resonance imaging (MRI) diagnostic pathway for men with suspected prostate cancer (PCa) and positive scans. To reduce unnecessary systematic biopsies (SBx), MRI-directed approaches comprising targeted plus regional biopsy (TBx + RBx) are being investigated.<h4>Objective</h4>To systematically evaluate the diagnostic performance of MRI-directed TBx + RBx approaches in comparison to MRI-directed TBx alone and TBx + SBx approaches.<h4>Evidence acquisition</h4>The MEDLINE and Embase databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses process. Identified reports were critically appraised according to the Quality AssessmentEuropean urology open science95-103https://www.ebi.ac.uk/biostudies/studies/S-EPMC9079161biostudies-literatureDiagnostic Performance of a Magnetic Resonance Imaging-directed Targeted plus Regional Biopsy Approach in Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis.PMC9079161Schoots IGvan der Poel HGFernandez Salamanca MPadhani ARvan Leeuwen PJHagens MJfalseDiagnostic Performance of a Magnetic Resonance Imaging-directed Targeted plus Regional Biopsy Approach in Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis.<h4>Context</h4>Systematic biopsies are additionally recommended to maximize the diagnostic performance of the magnetic resonance imaging (MRI) diagnostic pathway for men with suspected prostate cancer (PCa) and positive scans. To reduce unnecessary systematic biopsies (SBx), MRI-directed approaches comprising targeted plus regional biopsy (TBx + RBx) are being investigated.<h4>Objective</h4>To systematically evaluate the diagnostic performance of MRI-directed TBx + RBx approaches in comparison to MRI-directed TBx alone and TBx + SBx approaches.<h4>Evidence acquisition</h4>The MEDLINE and Embase databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses process. Identified reports were critically appraised according to the Quality Assessment2022-01-01T00:00:00Z2022 Jun2025-04-04T21:32:07.68Z2024-10-15T07:24:56.916ZS-EPMC90791613554070810.1016/j.euros.2022.04.001