{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["53"],"submitter":["Ma S"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation is a promising therapy for Alzheimer's disease (AD). However, hUC-MSCs cultured in vitro easily exhibit replicative senescence, which restricts their application. Although MG53 protein demonstrates multiple roles for a variety of cells and tissues repair, it remains unknown whether MG53 could rejuvenate senescent hUC-MSCs and enhance their efficacy in AD model. Here, we firstly presented that MG53 reinstated senescent hUC-MSCs via the activation of the Nrf2 signaling pathway by increasing cell proliferation and migration, ameliorating senescence and oxidative stress, and decreasing the release of senescence-associated secretory phenotype. In vivo studies showed that MG53 treatment improved the therapeutic effect"],"journal":["Redox biology"],"pagination":["102325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9079718"],"repository":["biostudies-literature"],"pubmed_title":["MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway."],"pmcid":["PMC9079718"],"pubmed_authors":["Ma S","Li Z","Guan F","Wang Y","Shi J","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway.","description":"Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation is a promising therapy for Alzheimer's disease (AD). However, hUC-MSCs cultured in vitro easily exhibit replicative senescence, which restricts their application. Although MG53 protein demonstrates multiple roles for a variety of cells and tissues repair, it remains unknown whether MG53 could rejuvenate senescent hUC-MSCs and enhance their efficacy in AD model. Here, we firstly presented that MG53 reinstated senescent hUC-MSCs via the activation of the Nrf2 signaling pathway by increasing cell proliferation and migration, ameliorating senescence and oxidative stress, and decreasing the release of senescence-associated secretory phenotype. In vivo studies showed that MG53 treatment improved the therapeutic effect","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-06-01T02:21:33.841Z","creation":"2024-11-14T19:57:42.623Z"},"accession":"S-EPMC9079718","cross_references":{"pubmed":["35525026"],"doi":["10.1016/j.redox.2022.102325"]}}